Fusilev Side Effects

Generic name: levoleucovorin calcium

Note: This document contains side effect information about levoleucovorin calcium. Some of the dosage forms listed on this page may not apply to the brand name Fusilev.

Some side effects of Fusilev may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to levoleucovorin calcium: intravenous powder for injection

Get emergency medical help if you have any of these signs of an allergic reaction while taking levoleucovorin calcium (the active ingredient contained in Fusilev) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your doctor or caregivers at once if you have a serious side effect such as:

• white patches or sores inside your mouth or on your lips;

• urinating more or less than usual;

• severe or ongoing diarrhea;

• feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;

• fever, chills;

• confusion; or

• trouble breathing.

Less serious side effects of levoleucovorin calcium may include:

• nausea, vomiting, diarrhea;

• stomach pain, upset stomach;

• numbness or tingling;

• loss of appetite, unusual or unpleasant taste in your mouth;

• weakness, tired feeling;

• hair loss; or

• mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to levoleucovorin calcium: intravenous powder for injection

Gastrointestinal

Gastrointestinal side effects including stomatitis (37.5%), vomiting (37.5%), nausea (18.8%), diarrhea (6.3%), dyspepsia (6.3%), and typhlitis (6.3%) have been reported.

Respiratory

Respiratory side effects including dyspnea (6.3%) have been reported.

Dermatologic

Dermatologic side effects including dermatitis (6.3%), pruritus, and rash have been reported.

Other

Other side effects including confusion (6.3%), taste perversion (6.3), temperature change, and rigors have been reported.

Nervous system

Nervous system side effects including neuropathy (6.3%) have been reported.

Renal

Renal side effects including abnormal renal function (6.3%) have been reported.

Hypersensitivity

Other side effects including confusion (6.3%), taste perversion (6.3), temperature change, and rigors have been reported.

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