Frovatriptan Side Effects
Some side effects of frovatriptan may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to frovatriptan: oral tablet
Along with its needed effects, frovatriptan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking frovatriptan:Less common
- Chest pain
Some side effects of frovatriptan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More Common
- Acid or sour stomach, belching, heartburn, indigestion, stomach discomfort, upset or pain
- dry mouth
- fatigue, such as unusual tiredness or weakness
- flushing, such as feeling of warmth, redness of the face, neck, arms and occasionally upper chest
- hot or cold sensation
- skeletal pain, such as pain in bones
- tingling, burning, or prickly sensations
- sleepiness or unusual drowsiness.
For Healthcare Professionals
Applies to frovatriptan: oral tablet
Cardiovascular side effects, some fatal, have occurred following the use of 5-HT1 agonists. These events are extremely rare and most have been reported in patients with risk factors predictive of CAD. Such effects include coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular tachycardia, and ventricular fibrillation.
Cardiovascular side effects reported with the use of frovatriptan have included palpitation (>1% of patients) and less frequently, tachycardia, abnormal electrocardiogram (ECG), and bradycardia.
Nervous system side effects reported during clinical trials included dizziness (8% vs. 5% placebo), headache (4% vs. 3% placebo), and paresthesia (4% vs. 2% placebo). Additional nervous system side effects reported with the use of frovatriptan have included infrequent cases of tremor, hyperesthesia, worsened migraine, involuntary muscle contractions, vertigo, ataxia, somnolence, abnormal gait and speech disorder. Hypertonia, hypotonia, syncope, abnormal reflexes and tongue paralysis were rarely reported during clinical trials involving frovatriptan. There have also been postmarketing reports of seizure in close temporal association with triptan use.
General side effects reported as frequent with the use of frovatriptan have included pain, fatigue, hot or cold sensation, and chest pain. Other general side effects reported less frequently have included asthenia, rigors, fever, hot flushes and malaise. Rarely reported general side effects of frovatriptan use have included feelings of relaxation, leg pain and mouth edema.
Gastrointestinal side effects reported most often during clinical trials included dry mouth (3% vs. 1% placebo) and dyspepsia (2% vs. 1% placebo). Additional gastrointestinal side effects reported as frequent during clinical trials of frovatriptan have included vomiting, nausea, abdominal pain, and diarrhea. Infrequently reported gastrointestinal side effects have included dysphagia, flatulence, constipation, anorexia, esophagospasm, and increased salivation. Rarely reported gastrointestinal side effects have included a change in bowel habits, chelitis, eructation, gastroesophageal reflux, hiccough, peptic ulcer, salivary gland pain, stomatitis, and toothache.
Psychiatric side effects reported as having occurred frequently during clinical trials involving frovatriptan have included insomnia and anxiety. Reported as infrequent psychiatric side effects were confusion, nervousness, agitation, euphoria, impaired concentration, depression, emotional lability, amnesia, thinking abnormally, and depersonalization. Reports of aggravated depression, abnormal dreaming, and personality disorder have rarely occurred.
Musculoskeletal side effects reported as having occurred frequently during clinical trials have included skeletal pain (3% vs. 2% placebo). Additional musculoskeletal side effects having occurred infrequently with the use of frovatriptan have included myalgia, back pain, arthralgia, arthrosis, leg cramps, and muscle weakness.
Respiratory side effects reported as having occurred frequently during clinical trials of frovatriptan have included sinusitis and rhinitis. Additional respiratory side effects have included infrequent reports of pharyngitis, dyspnea, hyperventilation and laryngitis.
Ocular side effects reported as having occurred frequently during clinical trials involving frovatriptan have included abnormal vision. Infrequently reported ocular side effects have included eye pain, conjunctivitis, and abnormal lacrimation.
Dermatologic side effects reported as having occurred frequently during clinical trials involving frovatriptan have included increased sweating. Infrequently reported dermatologic side effects have included pruritus and bullous eruption.
Other side effects reported as having occurred frequently during clinical trials involving frovatriptan have included tinnitus. Infrequently reported other side effects have included earache, hyperacusis, and taste perversion.
Genitourinary side effects have been reported infrequently with the use of frovatriptan and have included increased micturition frequency and polyuria. Additionally, rare reports of nocturia, renal pain, and abnormal urine have occurred.
Metabolic side effects have been reported infrequently with the use of frovatriptan and have included increased thirst and dehydration. Additionally, rare reports of hypocalcemia and hypoglycemia have occurred.
Hematologic side effects have been reported infrequently with the use of frovatriptan and have included epistaxis. Additionally, rare reports of purpura have occurred.
More about frovatriptan
- Other brands: Frova
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