Frova Side Effects

Generic Name: frovatriptan

Note: This page contains information about the side effects of frovatriptan. Some of the dosage forms included on this document may not apply to the brand name Frova.

Not all side effects for Frova may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to frovatriptan: oral tablet

In addition to its needed effects, some unwanted effects may be caused by frovatriptan (the active ingredient contained in Frova). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking frovatriptan:

Less common
  • Changes in vision
  • chest pain
  • fast, irregular, pounding, or racing heartbeat or pulse
  • increased sweating
Incidence not known
  • Abdominal or stomach pain
  • agitation
  • bloody diarrhea
  • cold fingers or toes
  • confusion
  • cough
  • diarrhea
  • difficulty swallowing
  • dizziness
  • fainting
  • fever
  • headache, sudden, severe, and continuing
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • numbness or tingling of the fingers or toes
  • overactive reflexes
  • pain spreading to the left shoulder
  • paleness or cold feeling in the fingertips and toes
  • poor coordination
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • restlessness
  • shivering
  • skin rash, hives, or itching skin
  • talking or acting with excitement you cannot control
  • tightness in the chest, throat, neck, and jaw
  • tingling or pain in the fingers or toes when exposed to cold
  • trembling or shaking
  • twitching
  • unusual tiredness or weakness
  • weakness in the legs

Some of the side effects that can occur with frovatriptan may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Acid or sour stomach
  • belching
  • bone pain
  • continuing ringing or buzzing or other unexplained noise in the ears
  • dry mouth
  • feeling of warmth
  • hearing loss
  • heartburn
  • hot or cold sensation
  • indigestion
  • pain or tenderness around the eyes and cheekbones
  • redness of the face, neck, arms, and occasionally upper chest
  • stomach discomfort or upset
  • stuffy or runny nose
  • trouble sleeping
Incidence not known
  • Seizures

For Healthcare Professionals

Applies to frovatriptan: oral tablet

Cardiovascular

Cardiovascular side effects, some fatal, have occurred following the use of 5-HT1 agonists. These events are extremely rare and most have been reported in patients with risk factors predictive of CAD. Such effects include coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular tachycardia, and ventricular fibrillation.

Cardiovascular side effects reported with the use of frovatriptan (the active ingredient contained in Frova) have included palpitation (>1% of patients) and less frequently, tachycardia, abnormal electrocardiogram (ECG), and bradycardia.

Nervous system

Nervous system side effects reported during clinical trials included dizziness (8% vs. 5% placebo), headache (4% vs. 3% placebo), and paresthesia (4% vs. 2% placebo). Additional nervous system side effects reported with the use of frovatriptan (the active ingredient contained in Frova) have included infrequent cases of tremor, hyperesthesia, worsened migraine, involuntary muscle contractions, vertigo, ataxia, somnolence, abnormal gait and speech disorder. Hypertonia, hypotonia, syncope, abnormal reflexes and tongue paralysis were rarely reported during clinical trials involving frovatriptan. There have also been postmarketing reports of seizure in close temporal association with triptan use.

General

General side effects reported as frequent with the use of frovatriptan (the active ingredient contained in Frova) have included pain, fatigue, hot or cold sensation, and chest pain. Other general side effects reported less frequently have included asthenia, rigors, fever, hot flushes and malaise. Rarely reported general side effects of frovatriptan use have included feelings of relaxation, leg pain and mouth edema.

Gastrointestinal

Gastrointestinal side effects reported most often during clinical trials included dry mouth (3% vs. 1% placebo) and dyspepsia (2% vs. 1% placebo). Additional gastrointestinal side effects reported as frequent during clinical trials of frovatriptan (the active ingredient contained in Frova) have included vomiting, nausea, abdominal pain, and diarrhea. Infrequently reported gastrointestinal side effects have included dysphagia, flatulence, constipation, anorexia, esophagospasm, and increased salivation. Rarely reported gastrointestinal side effects have included a change in bowel habits, chelitis, eructation, gastroesophageal reflux, hiccough, peptic ulcer, salivary gland pain, stomatitis, and toothache.

Psychiatric

Psychiatric side effects reported as having occurred frequently during clinical trials involving frovatriptan (the active ingredient contained in Frova) have included insomnia and anxiety. Reported as infrequent psychiatric side effects were confusion, nervousness, agitation, euphoria, impaired concentration, depression, emotional lability, amnesia, thinking abnormally, and depersonalization. Reports of aggravated depression, abnormal dreaming, and personality disorder have rarely occurred.

Musculoskeletal

Musculoskeletal side effects reported as having occurred frequently during clinical trials have included skeletal pain (3% vs. 2% placebo). Additional musculoskeletal side effects having occurred infrequently with the use of frovatriptan (the active ingredient contained in Frova) have included myalgia, back pain, arthralgia, arthrosis, leg cramps, and muscle weakness.

Respiratory

Respiratory side effects reported as having occurred frequently during clinical trials of frovatriptan (the active ingredient contained in Frova) have included sinusitis and rhinitis. Additional respiratory side effects have included infrequent reports of pharyngitis, dyspnea, hyperventilation and laryngitis.

Ocular

Ocular side effects reported as having occurred frequently during clinical trials involving frovatriptan (the active ingredient contained in Frova) have included abnormal vision. Infrequently reported ocular side effects have included eye pain, conjunctivitis, and abnormal lacrimation.

Dermatologic

Dermatologic side effects reported as having occurred frequently during clinical trials involving frovatriptan (the active ingredient contained in Frova) have included increased sweating. Infrequently reported dermatologic side effects have included pruritus and bullous eruption.

Other

Other side effects reported as having occurred frequently during clinical trials involving frovatriptan (the active ingredient contained in Frova) have included tinnitus. Infrequently reported other side effects have included earache, hyperacusis, and taste perversion.

Genitourinary

Genitourinary side effects have been reported infrequently with the use of frovatriptan (the active ingredient contained in Frova) and have included increased micturition frequency and polyuria. Additionally, rare reports of nocturia, renal pain, and abnormal urine have occurred.

Metabolic

Metabolic side effects have been reported infrequently with the use of frovatriptan (the active ingredient contained in Frova) and have included increased thirst and dehydration. Additionally, rare reports of hypocalcemia and hypoglycemia have occurred.

Hematologic

Hematologic side effects have been reported infrequently with the use of frovatriptan (the active ingredient contained in Frova) and have included epistaxis. Additionally, rare reports of purpura have occurred.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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