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Fluticasone topical Side Effects

Not all side effects for fluticasone topical may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to fluticasone topical: topical application cream, topical application lotion, topical application ointment

In addition to its needed effects, some unwanted effects may be caused by fluticasone topical. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking fluticasone topical:

Less common
  • Burning, itching, redness, or stinging of the skin
  • hives or welts, skin rash
  • raised, dark red, wart-like spots on the skin, especially when used on the face
  • Burning, itching, and pain in hairy areas, pus at the root of the hair
Incidence not known
  • Darkening of the skin
  • diarrhea
  • dizziness
  • fainting
  • loss of appetite
  • mental depression
  • nausea
  • thinning of the skin with easy bruising, especially when used on the face or where the skin folds together (eg, between the fingers)
  • unusual tiredness or weakness
  • vomiting

Some of the side effects that can occur with fluticasone topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Body aches or pain
  • change in hearing
  • chills
  • common cold
  • cough
  • difficulty with breathing
  • dry skin
  • ear congestion
  • ear drainage
  • earache or pain in the ear
  • fever
  • headache
  • increased hair growth on the forehead, back, arms, and legs
  • lightheadedness
  • loss of voice
  • nasal congestion
  • runny nose
  • sneezing
  • sore throat

For Healthcare Professionals

Applies to fluticasone topical: topical cream, topical lotion, topical ointment


Common (1% to 10 %): Erythema, burning, stinging[Ref]


Very rare (less than 0.01%): Hypothalamic-pituitary-adrenal (HPA) axis suppression, Increased weight, obesity, delayed weight gain, growth retardation in children, cushingoid features (e.g. moon face, central obesity), decreased endogenous cortisol levels[Ref]

Nervous system

Frequency not reported: Intracranial hypertension (including bulging fontanelles, headaches, bilateral papilledema)[Ref]


Common (1% to 10%): Erythematous rash, facial telangiectasia, non-facial telangiectasia, urticaria, pruritus
Uncommon (0.1% to 1%): Skin infection, infected eczema, impetigo, atopic dermatitis, eczema, skin irritation, folliculitis, blisters, dryness of skin, local skin burning
Frequency not reported: Irritation, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, skin atrophy, striae, hypertrichosis, miliaria, pustular psoriasis[Ref]


Very rare (less than 0.01%): Hypertension[Ref]


Very rare (less than 0.01%): Osteoporosis[Ref]


Very rare (less than 0.01%): Cataract, glaucoma[Ref]


Uncommon (0.1% to 1%): Viral warts, herpes simplex
Very rare (less than 0.01%): Opportunistic infections[Ref]


Very rare (less than 0.01%): Hypersensitivity[Ref]


The most commonly reported side effects were erythema, burning, and stinging.[Ref]


1. "Product Information. Flovent (fluticasone)." Glaxo Wellcome, Research Triangle Park, NC.

2. "Product Information. Flonase (fluticasone)." Glaxo Wellcome, Research Triangle Park, NC.

3. "Product Information. Cutivate (fluticasone)." Glaxo Wellcome, Research Triangle Park, NC.

4. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

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