Fluoroplex Side Effects
Please note - some side effects for Fluoroplex may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
Side Effects of Fluoroplex - for the Consumer
Fluoroplex Cream
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Fluoroplex Cream:
Seek medical attention right away if any of these SEVERE side effects occur when using Fluoroplex Cream:Burning, crusting, redness, pain, soreness, inflammation, or irritation of the skin.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody diarrhea; change in skin color; chills; fever; scarring or sores on the treated area; severe or persistent burning, crusting, redness, pain, soreness, inflammation, or irritation of the skin; severe stomach pain; vomiting.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
TopFluoroplex Side Effects - for the Professional
Fluoroplex
Pain, pruritus, burning, irritation, inflammation, allergic contact dermatitis and telangiectasia have been reported. Occasionally, hyperpigmentation and scarring have also been reported.
TopSide Effects by Body System - for Healthcare Professionals
Dermatologic
Dermatologic side effects have been the most frequently reported and include local burning, crusting, allergic contact dermatitis, erosions, erythema, hyperpigmentation, irritation, pain, photosensitivity, pruritus, scarring, rash, soreness, and ulceration, and other local reactions.
The following side effects have been reported infrequently and a causal relationship is remote: alopecia, blistering, bullous pemphigoid, discomfort, ichthyosis, scaling, suppuration, swelling, telangiectasia, tenderness, urticaria, and skin rash.
Other
One case of life-threatening systemic toxicity was associated with fluorouracil topical 5% cream in a patient with dihydropyrimidine dehydrogenase enzyme deficiency. Signs and symptoms included severe abdominal pain, bloody diarrhea, vomiting, fever, chills, stomatitis, erythematous rash, neutropenia, thrombocytopenia, and inflammation of the esophagus, stomach and small intestine.
Other
Miscarriages and a birth defect (ventricular septal defect) have been reported when fluorouracil was applied to mucous membrane areas of pregnant women. A cleft lip and palate have been reported when fluorouracil was applied as recommended.
Hematologic
Hematologic side effects have included leukocytosis, which has been the most frequently reported hematologic side effect. Eosinophilia, thrombocytopenia, and toxic granulation have been reported infrequently and a causal relationship is remote.
Nervous system
Nervous system side effects have been reported infrequently and a causal relationship is remote. These included emotional upset, insomnia and irritability.
Gastrointestinal
Gastrointestinal side effects have been reported rarely and a causal relationship is remote. These include medicinal taste and stomatitis.
Ocular
Ocular side effects have been reported infrequently and a causal relationship is remote. These include conjunctival and corneal reactions, and lacrimation.
Other
Nasal irritation has been reported infrequently and a causal relationship is remote.
Other
Herpes simplex has been reported infrequently and a causal relationship is remote.
TopMore Fluoroplex resources
- Fluoroplex Prescribing Information (FDA)
- Fluoroplex Cream MedFacts Consumer Leaflet (Wolters Kluwer)
- Fluoroplex Concise Consumer Information (Cerner Multum)
- Fluoroplex Topical Advanced Consumer (Micromedex) - Includes Dosage Information
- Carac Prescribing Information (FDA)
- Efudex Prescribing Information (FDA)
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