Flumadine Side Effects
Generic Name: rimantadine
Note: This document contains side effect information about rimantadine. Some of the dosage forms listed on this page may not apply to the brand name Flumadine.
Some side effects of Flumadine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to rimantadine: oral syrup, oral tablet
Along with its needed effects, rimantadine (the active ingredient contained in Flumadine) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking rimantadine:Less common
- Difficult or labored breathing
- shortness of breath
- tightness in the chest
Get emergency help immediately if any of the following symptoms of overdose occur while taking rimantadine:Symptoms of overdose
- chest pain or discomfort
- dry mouth
- fast, slow, or irregular heartbeat
- irregular heartbeats
- pounding or rapid pulse
- seeing, hearing, or feeling things that are not there
- trouble with sleeping
Some side effects of rimantadine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less common
- Abdominal or stomach pain
- acid or sour stomach
- continuing ringing or buzzing or other unexplained noise in the ears
- difficulty with concentrating
- hearing loss
- impaired concentration
- lack or loss of strength
- loss of appetite
- shakiness and unsteady walk
- sleepiness or unusual drowsiness
- stomach discomfort, upset, or pain
- unsteadiness, trembling, or other problems with muscle control or coordination
- unusual tiredness or weakness
For Healthcare Professionals
Applies to rimantadine: oral syrup, oral tablet
Gastrointestinal and nervous system side effects are most frequently reported. In a prophylaxis trial, 6.9% of subjects discontinued treatment due to adverse reactions. In geriatric patients, gastrointestinal and nervous system adverse effects occurred twice as often with rimantadine (the active ingredient contained in Flumadine) than with placebo.
Seizures were reported in a few patients during clinical trials with rimantadine (the active ingredient contained in Flumadine) In two patients, seizure activity had been absent for greater than 10 years. However, their anticonvulsant medications had been withdrawn in the previous few months.
Nervous system side effects have included insomnia (up to 3.4%), dizziness (up to 1.9%), headache (1.4%), and jitteriness. Ataxia, somnolence, agitation, and tinnitus have been reported in 0.3% to 1% of patients. Gait abnormality, hyperkinesia, tremor, hallucination, confusion, syncope, taste loss/change, parosmia, and convulsions have been reported in less than 0.3% of patients. Agitation and hypesthesia have occurred with higher than recommended doses of rimantadine. Dizziness and headache were reported up to two times more often in geriatric patients receiving rimantadine than in those receiving placebo.
Gastrointestinal side effects have included nausea (2.8%), vomiting (1.7%), anorexia (1.6%), dry mouth (1.5%), and abdominal pain (1.4%). Diarrhea and dyspepsia have been reported in 0.3% to 1% of patients. Constipation, dysphagia, and stomatitis have occurred with higher than recommended doses of rimantadine (the active ingredient contained in Flumadine) Gastrointestinal symptoms (particularly nausea, vomiting, and abdominal pain) were reported at least twice as often in geriatric patients receiving rimantadine than in those receiving placebo. Tolerance may be improved by giving the drug in two divided daily doses.
Psychiatric side effects have included impaired concentration (up to 2.1%), nervousness (up to 2.1%), depression (up to 1%), and euphoria (less than 0.3%). Anxiety was reported up to two times more often in geriatric patients receiving rimantadine (the active ingredient contained in Flumadine) than in those receiving placebo.
Cardiovascular side effects have included cardiac failure, cerebrovascular disorder, heart block, hypertension, palpitation, pedal edema, and tachycardia in less than 0.3% of patients.
Respiratory side effects have included dyspnea (0.3% to 0.1%), bronchospasm (less than 0.3%), and cough (less than 0.3%).
Other side effects have included asthenia (1.4%), fatigue (1%), and pallor (less than 0.3%). Fever and rigors have occurred with higher than recommended doses of rimantadine (the active ingredient contained in Flumadine) Asthenia and fatigue were reported up to two times more often in geriatric patients receiving rimantadine than in those receiving placebo.
Dermatologic side effects have included rash (0.3% to less than 1%). Diaphoresis has occurred with higher than recommended doses of rimantadine (the active ingredient contained in Flumadine)
Genitourinary side effects have included nonpuerperal lactation in less than 0.3% of patients. Increased micturition frequency has occurred with higher than recommended doses of rimantadine (the active ingredient contained in Flumadine)
Ocular side effects have included increased lacrimation and eye pain with higher than recommended doses of rimantadine (the active ingredient contained in Flumadine)
More about Flumadine (rimantadine)
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