FIRST-Progesterone VGS 400 Side Effects
Generic Name: progesterone, prochieve, progestins
Please note - some side effects for FIRST-Progesterone VGS 400 may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
Side Effects by Body System - for Healthcare Professionals
Applies to: compounding powder; intramuscular solution; oral capsule; topical cream; vaginal gel; vaginal suppository; vaginal tablet
Genitourinary
Genitourinary side effects have included breast tenderness (27%), urinary problems (11%), vaginal discharge (10%), vaginal dryness (6%), breast pain (6%), breast carcinoma (2%), breast excisional biopsy (2%), breast enlargement, leukorrhea, uterine fibroid, vaginal dryness, fungal vaginitis, vaginitis, dysuria, cystitis, and urinary tract infection
Nervous system
Nervous system side effects have included headache (31%), dizziness (15%), confusion, somnolence, asthenia, increased sweating, nervousness, migraine, tremor, and speech disorder. Syncope (with and without hypotension) have been reported.
Cardiovascular
Cardiovascular side effects have included chest pain (7%), hypertension, angina pectoris, syncope, and palpitations.
Gastrointestinal
Gastrointestinal side effects have included abdominal pain (20%), bloating (8%), diarrhea (8%), nausea (8%), constipation (3%), dyspepsia, dry mouth, gastroenteritis, hemorrhagic rectum, hiatus hernia, and vomiting. The side effects reported during clinical studies evaluating the use of progesterone gel 8% have included constipation (27%), nausea (22%), and diarrhea (8%).
Musculoskeletal
Musculoskeletal side effects have included joint pain (20%), musculoskeletal pain (12%), back pain (8%), arthritis, leg cramps, hypertonia, muscle disorder, and myalgia.
Psychiatric
Psychiatric side effects have included depression (19%), anxiety, impaired concentration, insomnia, forgetfulness, and personality disorder.
Respiratory
Respiratory side effects have included cough (8%), bronchitis, nasal congestion, pharyngitis, pneumonitis, and sinusitis.
Dermatologic
Dermatologic side effects have included acne, pruritus, rash, skin discoloration, seborrhea, verruca, and wound debridement during therapy.
Additional dermatologic side effects have included case reports of familial autoimmune dermatitis.
Ocular
Ocular side effects have included abnormal vision.
Hepatic
Hepatic side effects including reversible cases of hepatitis, elevated transaminases, and cholecystectomy have been reported.
Other
Other side effects have included viral infection (12%), hot flashes (11%), fatigue (8%), irritability (8%), worry (8%), night sweats (7%), earache, tooth disorder, anorexia, increased appetite, peripheral edema, edema, accidental injury, fever, abscess, lymphadenopathy, and herpes simplex.
Immunologic
Immunologic side effects have included autoimmune dermatitis during the luteal phase of the menstrual cycle. Test results using interferon gamma release in vivo and vitro tests confirmed the diagnosis.
Local
Local side effects have included pain, irritation, and redness at the injection site.
Top- Progesterone Natural MedFacts for Professionals (Wolters Kluwer)
- Progesterone Professional Patient Advice (Wolters Kluwer)
- Progesterone Prescribing Information (FDA)
- progesterone Advanced Consumer (Micromedex) - Includes Dosage Information
- Progesterone Monograph (AHFS DI)
- progesterone MedFacts Consumer Leaflet (Wolters Kluwer)
- Crinone Prescribing Information (FDA)
- Crinone gel MedFacts Consumer Leaflet (Wolters Kluwer)
- Crinone Advanced Consumer (Micromedex) - Includes Dosage Information
- Endometrin Prescribing Information (FDA)
- Endometrin insert MedFacts Consumer Leaflet (Wolters Kluwer)
- Endometrin Consumer Overview
- Prochieve gel MedFacts Consumer Leaflet (Wolters Kluwer)
- Prochieve Prescribing Information (FDA)
- Progestins Monograph (AHFS DI)
- Prometrium Prescribing Information (FDA)
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