Fexofenadine / pseudoephedrine Side Effects
Some side effects of fexofenadine / pseudoephedrine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to fexofenadine / pseudoephedrine: oral tablet extended release, oral tablet extended release 24 hr
Along with its needed effects, fexofenadine / pseudoephedrine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking fexofenadine / pseudoephedrine:More common
- Trouble in sleeping
- irregular heartbeat
- sore throat
- Difficult or labored breathing
- difficulty swallowing
- fast heartbeat
- feeling of warmth
- hives or welts
- itching skin
- itching, puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
- large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs
- reddening of the skin, especially around ears
- redness of the face, neck, arms and occasionally, upper chest
- shortness of breath
- skin rash
- tightness in chest
- swelling of eyes, face, or inside of nose
- unusual tiredness or weakness
Some side effects of fexofenadine / pseudoephedrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Abdominal or stomach pain
- back pain
- dry mouth
- Terrifying dreams causing sleep disturbances
For Healthcare Professionals
Applies to fexofenadine / pseudoephedrine: oral tablet extended release
Gastrointestinal side effects have included nausea (7.4%), dry mouth (2.8%), dyspepsia (2.8%), throat irritation (2.3%), and abdominal pain (1.4%).
Cardiovascular side effects have included palpitations (1.9%).
Pseudoephedrine causes vasoconstriction which generally does not produce hypertension, but may be problematic for patients with preexisting hypertension. Arrhythmias may be produced in predisposed patients. Rarely, pseudoephedrine has been reported to cause coronary artery spasm and chest pain.
One report evaluated the effect with 60 mg of pseudoephedrine on individuals in a hyperbaric chamber at 1 atmosphere (simulated scuba dive to 66 feet of sea water). Pseudoephedrine and depth (simulated) were found to have significant but opposite effects on heart rate, although these effects were unlikely to be clinically significant during diving.
Nervous system side effects have included headache (13%), insomnia (12.6%), dizziness (1.9%), agitation (1.9%), nervousness (1.4%), and anxiety (1.4%).
In rare cases, rash urticaria, pruritus, angioedema, chest tightness, dyspnea, flushing and systemic anaphylaxis have been reported.
Hypersensitivity reactions have included fixed drug eruptions.
Respiratory side effects have included upper respiratory infections (1.4%).
Musculoskeletal side effects have included back pain (1.9%).
More about fexofenadine/pseudoephedrine
- Fexofenadine/pseudoephedrine extended-release tablets
- Fexofenadine/pseudoephedrine extended-release tablets (12 hour)
- Fexofenadine and pseudoephedrine
- Fexofenadine and pseudoephedrine (Advanced Reading)
- Fexofenadine and Pseudoephedrine (FDA)
- Fexofenadine Hydrochloride/Pseudoephedrine Hydrochloride (Wolters Kluwer)
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