Felodipine Side Effects
Not all side effects for felodipine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to felodipine: oral tablet extended release
In addition to its needed effects, some unwanted effects may be caused by felodipine. In the event that any of these side effects do occur, they may require medical attention.
You should check with your doctor immediately if any of these side effects occur when taking felodipine:More common
- Bloating or swelling of face, arms, hands, lower legs, or feet
- rapid weight gain
- tingling of hands or feet
- unusual weight gain or loss
- Body aches or pain
- difficulty in breathing
- ear congestion
- loss of voice
- nasal congestion
- runny nose
- sore throat
- unusual tiredness or weakness
- Blurred vision
- chest pain, tightness, or heaviness
- cough producing mucus
- dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
- fast, slow, or irregular heartbeat
- general feeling of discomfort or illness
- joint pain
- large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- loss of appetite
- muscle aches and pains
- pain or discomfort in arms, jaw, back, or neck
- pale skin
- shortness of breath
- swelling or puffiness of face
- tender or swollen glands in neck
- trouble in swallowing
- trouble sleeping
- troubled breathing with exertion
- unusual bleeding or bruising
- voice changes
If any of the following symptoms of overdose occur while taking felodipine, get emergency help immediately:Symptoms of overdose
- Feeling of warmth
- redness of the face, neck, arms and occasionally, upper chest
Some of the side effects that can occur with felodipine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:Less common
- Acid or sour stomach
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- lack or loss of strength
- skin rash
- stomach discomfort, upset, or pain
- Bleeding gums
- irritation in mouth
- redness and swelling of gums
- Bloated or full feeling
- bloody nose
- burning while urinating
- decreased interest in sexual intercourse
- difficult or painful urination
- difficulty in moving
- disturbed color perception
- double vision
- dry mouth
- excess air or gas in stomach or intestines
- feeling sad or empty
- fear or nervousness
- frequent strong or increased urge to urinate
- halos around lights
- hives or welts
- inability to have or keep an erection
- increased need to urinate
- increased volume of pale or dilute urine
- loss in sexual ability, desire, drive, or performance
- loss of interest or pleasure
- muscle cramps or stiffness
- night blindness
- overbright appearance of lights
- pain or tenderness around eyes and cheekbones
- passing gas
- passing urine more often
- redness of skin
- sleepiness or unusual drowsiness
- sores, welting, or blisters
- swelling of the breasts or breast soreness in both females and males
- swollen joints
- trouble concentrating
- tunnel vision
- unable to sleep
For Healthcare Professionals
Applies to felodipine: oral tablet extended release
Side effects of felodipine were generally mild and transient. The most common side effects reported with felodipine given at 2.5 to 10 mg per day were peripheral edema and headache. Therapy was discontinued due to adverse drug events in about 6% of patients, primarily for peripheral edema, headache or flushing.
A dose of 20 mg per day has been evaluated in some clinical trials. Although 20 mg per day increased the antihypertensive effect of felodipine, a disproportionate increase in side effects, especially those associated with vasodilatory effects, was reported.
Peripheral edema was generally mild, but it was age and dose related. It resulted in treatment discontinuation in about 3% of patients.
Other side effects have included peripheral edema (up to 17.4%), flushing (up to 6.9%), asthenia (up to 3.9%), warm sensation (up to 1.5%), chest pain, facial edema, and influenza-like illness.
Nervous system side effects have included headache (up to 14.7%), dizziness (up to 3.7%), paresthesia (up to 1.6%), syncope, insomnia, and somnolence.
Cardiovascular side effects have included palpitation (up to 2.5%), myocardial infarction, hypotension, angina pectoris, arrhythmia, tachycardia, premature beats, and leukocytoclastic vasculitis. A few rare cases of felodipine-induced telangiectasia have been reported.
Gastrointestinal side effects have included dyspepsia (up to 3.9%), nausea (up to 1.7%), constipation (1.5%), abdominal pain, diarrhea, vomiting, dry mouth, flatulence, and acid regurgitation. Gingival hyperplasia, usually mild, has been reported in less than 0.5% of patients.
Gingival hyperplasia has been avoided or has regressed with good dental hygiene.
Respiratory side effects have included upper respiratory infection (up to 3.9%), cough (up to 1.7%), rhinorrhea (up to 1.6%), sneezing (up to 1.6%), dyspnea, pharyngitis, bronchitis, influenza, sinusitis, epistaxis, and respiratory infection.
Dermatologic side effects have included rash (up to 2%), angioedema, contusion, erythema, and urticaria.
Hematologic side effects have included anemia.
Musculoskeletal side effects have included arthralgia, back pain, leg pain, foot pain, muscle cramps, myalgia, arm pain, knee pain, and hip pain.
Hepatic side effects have included elevated ALT (SGPT) and unspecified serum transaminases.
In clinical studies, one of two episodes of elevated serum transaminases decreased following drug discontinuation; no follow-up was available for the second patient.
Psychiatric system side effects have included depression, anxiety disorders, irritability, nervousness, and decreased libido.
Genitourinary side effects have included gynecomastia, impotence, urinary frequency, urinary urgency, dysuria, and polyuria.
Ocular system side effects have included visual disturbances.
More about felodipine
- Other brands: Plendil
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