Ezfe Side Effects

Generic Name: iron polysaccharide

Note: This page contains information about the side effects of iron polysaccharide. Some of the dosage forms included on this document may not apply to the brand name Ezfe.

Not all side effects for Ezfe may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to iron polysaccharide: elixir

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; darkened or green stools; diarrhea; nausea; stomach upset.

Seek medical attention right away if any of these SEVERE side effects occur while taking iron polysaccharide (the active ingredient contained in Ezfe)

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; blood or streaks of blood in the stool; fever; vomiting, especially with continuing sharp stomach pain.

For Healthcare Professionals

Applies to iron polysaccharide: oral capsule, oral elixir, oral liquid, oral tablet

Gastrointestinal

Gastrointestinal side effects have been reported the most frequently. They have included nausea, vomiting, diarrhea, constipation, abdominal pain, flatulence, and heartburn.[Ref]

Constipation may be relieved by administering docusate sodium 100 mg to 200 mg per day in addition to increasing the intake of oral fluids, such as water.[Ref]

Other

Other side effects have included iron overload (hemosiderosis). Secondary hemochromatosis due to prolonged iron ingestion has been reported rarely.[Ref]

Iron overload (i.e., hemosiderosis) has been reported in patients genetically predisposed, or have underlying disorders, that augment the absorption of iron. It has also occurred following administration of excessive parenteral iron therapy, combination of oral and parenteral iron, or in patients with hemoglobinopathies that were erroneously diagnosed as iron deficiency anemia. Hemosiderosis is treated with repeated phlebotomy or long-term administration of deferoxamine. The liver is particularly susceptible to toxicity in iron-overload states.[Ref]

References

1. Wingard RL, Parker RA, Ismail N, Hakim RM "Efficacy of oral iron therapy in patients receiving recombinant human erythropoietin." Am J Kidney Dis 25 (1995): 433-9

2. KleinSchwartz W "Toxicity of polysaccharid-iron complex exposures reported to poison control centers." Ann Pharmacother 34 (2000): 165-9

3. Glassman E "Oral iron therapy with ferrous fumarate and polysaccharide iron complex." ANNA J 19 (1992): 277-8,323

4. "Multum Information Services, Inc. Expert Review Panel"

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