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Exemestane Side Effects

Not all side effects for exemestane may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to exemestane: oral tablet

In addition to its needed effects, some unwanted effects may be caused by exemestane. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking exemestane:

More common
  • Cough or hoarseness
  • difficult or labored breathing
  • fever or chills
  • increased blood pressure
  • lower back or side pain
  • mental depression
  • shortness of breath
  • swelling of the hands, ankles, feet, or lower legs
  • tightness in the chest
Less common
  • Chest pain
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • headache
  • sore throat
  • unexplained broken bones
  • wheezing
Incidence not known
  • Abdominal or stomach pain
  • clay-colored stools
  • confusion
  • dark urine
  • decreased urine output
  • diarrhea
  • difficulty with speaking
  • dilated neck veins
  • dizziness
  • double vision
  • inability to move the arms, legs, or facial muscles
  • inability to speak
  • irregular breathing
  • irregular heartbeat
  • itching
  • loss of appetite
  • nausea
  • rash
  • slow speech
  • unpleasant breath odor
  • unusual tiredness or weakness
  • vomiting of blood
  • weight gain
  • yellow eyes or skin

Some of the side effects that can occur with exemestane may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Anxiety
  • constipation
  • general feeling of discomfort or illness
  • general feeling of tiredness or weakness
  • hot flashes
  • increased sweating
  • pain
  • trouble with sleeping
Less common
  • Back pain
  • bone pain
  • burning, tingling, or prickly sensations
  • decreased sense of touch
  • increased appetite
  • joint pain
  • loss of hair
  • runny nose
  • stomach upset
  • weakness, generalized

For Healthcare Professionals

Applies to exemestane: oral tablet

Musculoskeletal

Very common (10% or more): Arthralgia (28.8%)
Common (1% to 10%): Pain in limb, back pain, osteoarthritis, myalgia, pathological fracture, hypoesthesia, skeletal pain, osteoporosis, muscle cramp
Uncommon (0.1% to 1%): Osteoporotic fracture[Ref]

General

The most commonly reported side effects were hot flushes, arthralgia, and fatigue.[Ref]

Immunologic

Common (1% to 10%): Infection[Ref]

Gastrointestinal

Very Common (10% or more): Nausea (up to 18%), abdominal pain (up to 11%)
Common (1% to 10%): Diarrhea, vomiting, constipation, dyspepsia
Uncommon (0.1% to 1%): Gastric ulcers[Ref]

Dermatologic

Very common (10% or more): Increased sweating (17.8%), alopecia (15.1%)
Common (1% to 10%): Dermatitis
Postmarketing reports: Urticaria, pruritus, acute generalized exanthemos pustulosis[Ref]

Cardiovascular

Very common (10% or more): Hot flushes (up to 32.9%), Hypertension (15.1%)
Common (1% to 10%): Lymphedema, chest pain
Uncommon (0.1% to 1%): Thromboembolism, myocardial infarction[Ref]

Hepatic

Very common (10% or more): Elevation of liver function tests (including enzymes, bilirubin, and alkaline phosphatase)
Postmarketing reports: Hepatitis including cholestatic hepatitis[Ref]

Psychiatric

Very common (10% or more): Insomnia (13.7%)
Common (1% to 10%): Depression, anxiety, confusion[Ref]

Nervous system

Very common (10% or more): Headache (13.6%), dizziness (10%)
Common (1% to 10%): Paresthesia, carpal tunnel syndrome
Uncommon (0.1% to 1%): Somnolence, neuropathy[Ref]

Respiratory

Very common (10% or more): Dyspnea
Common (1% to 10%): Coughing, bronchitis, sinusitis, upper respiratory tract infection, pharyngitis, rhinitis[Ref]

Ocular

Common (1% to 101%): Visual disturbances[Ref]

Oncologic

Common (1% to 10%): Other primary cancer[Ref]

Hypersensitivity

Postmarketing reports: Hypersensitivity[Ref]

Other

Very common (10% or more): Fatigue (up to 22.2%), pain (13%)
Common (1% to 10%): Edema, influenza-like symptoms, fever, generalized weakness, pain at tumor sites, asthenia, peripheral edema[Ref]

Metabolic

Common (1% to 10%): Increased appetite, anorexia, hypercholesterolemia[Ref]

Genitourinary

Very common (10% or more): Gynecological (10.5%)
Common (1% to 10%): Urinary tract infection, vaginal hemorrhage
Uncommon (0.1% to 1%): Uterine polyp, uterine polydectomy
Rare (less than 0.1%): Endometrial hyperplasia[Ref]

Hematologic

Very common (10% or more): Decrease in lymphocytes (20%)
Uncommon (0.1%to 1%): Thrombocytopenia, leucopenia[Ref]

References

1. "Product Information. Aromasin (exemestane)" Pharmacia & Upjohn, Kalamazoo, MI.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

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