Evarrest Side Effects

Generic Name: fibrin sealant topical

Note: This document contains side effect information about fibrin sealant topical. Some of the dosage forms listed on this page may not apply to the brand name Evarrest.

Some side effects of Evarrest may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to fibrin sealant topical: topical kit, topical solution

Fibrin sealant topical is made from human plasma (part of the blood) and may contain infectious agents (e.g., viruses) that can cause disease. Although fibrin sealant topical (the active ingredient contained in Evarrest) is screened, tested, and treated to reduce the possibility that it carries an infectious agent, it can still potentially transmit disease. Discuss with your doctor the risks and benefits of using fibrin sealant topical.

Contact your doctor if you develop fever, drowsiness, chills, runny nose, rash, joint pain, poor appetite, tiredness, nausea, vomiting, abdominal pain, dark-colored urine, or yellowing of the skin or eyes following treatment with fibrin sealant topical. These may be symptoms of infections that may occur due to use of this product.

Notify your doctor immediately if you experience a rare but serious allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives) to fibrin sealant topical.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to fibrin sealant topical: topical kit, topical solution


General side effects have been reported including rare reports of serious adverse events such as paralysis and other compressive complications possibly related to the use of fibrin sealant in combination with resorbable hemostatic agents. There have also been rare reports of fatalities following the misadministration of topical thrombin.


Hypersensitivity side effects such as anaphylactic and anaphylactoid reactions including shock have been reported rarely.


Cardiovascular side effects including tachycardia, bradycardia, hypotension, and thromboembolic complications have been reported rarely.


Respiratory side effects including severe dyspnea have been reported rarely.


Dermatologic side effects including flush, urticaria, and pruritus have been reported rarely.


Gastrointestinal side effects including nausea have been reported rarely.


A D-dimer is a fragment produced during the degradation of a clot. Postoperatively increased D-dimers may result at least partly from the degradation of fibrin sealant.

Other side effects including increased D-dimer levels have been reported in a clinical study on cardiovascular surgery, but did not exceed values reported in the literature occurring after this type of surgery.

More about Evarrest (fibrin sealant topical)

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