Ethionamide Side Effects
Some side effects of ethionamide may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to ethionamide: oral tablet
If you experience any of the following serious side effects, stop taking ethionamide and seek emergency medical attention:
an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
yellow skin or eyes;
numbness or tingling in your hands or feet;
blurred or double vision; or
confusion or abnormal behavior.
Other, less serious side effects may be more likely to occur. Continue to take ethionamide and talk to your doctor if you experience
nausea, vomiting, or loss of appetite;
a metallic taste in your mouth;
unusual fatigue or weakness;
tremors (shaking); or
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
For Healthcare Professionals
Applies to ethionamide: oral tablet
Gastrointestinal side effects are the most common side effects of ethionamide and may be dose-related. They have included nausea, vomiting, diarrhea, abdominal pain excessive salivation, metallic taste, stomatitis, anorexia, and weight loss. Approximately one-half of patients cannot tolerate 1 gram as a single dose.
Nervous system side effects have included psychotic disturbances, mental depression, drowsiness, dizziness, restlessness, headache, peripheral neuritis, and a pellagra-like syndrome. Concomitant pyridoxine has been recommended to prevent or relieve neurotoxic effects.
Ocular side effects have rarely included optic neuritis, diplopia, and blurred vision.
Hepatic side effects have included transient increases in serum bilirubin, SGOT, SGPT, and hepatitis with or without jaundice.
Hypersensitivity reactions have rarely included rash, photosensitivity, thrombocytopenia, and purpura.
Metabolic side effects have included hypoglycemia and hypothyroidism.
Genitourinary side effects have included gynecomastia and impotence.
Dermatologic side effects have included rash and acne.
Hematologic side effects have included thrombocytopenia and purpura.
Cardiovascular side effects have included postural hypotension.
More ethionamide resources
- ethionamide Concise Consumer Information (Cerner Multum)
- ethionamide MedFacts Consumer Leaflet (Wolters Kluwer)
- ethionamide Advanced Consumer (Micromedex) - Includes Dosage Information
- Ethionamide Professional Patient Advice (Wolters Kluwer)
- Ethionamide Monograph (AHFS DI)
- Trecator Prescribing Information (FDA)
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