Ethionamide Side Effects

Brand Names: Trecator

Please note - some side effects for Ethionamide may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Ethionamide - for the consumer

Ethionamide

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Ethionamide:

Diarrhea; dizziness; drowsiness; headache; increased salivation; loss of appetite; metallic taste; mouth sores; nausea; restlessness; stomach pain; vomiting; weight loss.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in sense of smell; depression; easy bruising or bleeding; low blood sugar (eg, increased heartbeat, headache, chills, sweating, tremor, increased hunger, changes in vision, nervousness, weakness, dizziness, drowsiness, fainting); tingling of hands or feet; vision changes (eg, loss of vision); yellowing of the skin or eyes.

By body system

Gastrointestinal side effects

Gastrointestinal side effects are the most common side effects of ethionamide and may be dose-related. They have included nausea, vomiting, diarrhea, abdominal pain excessive salivation, metallic taste, stomatitis, anorexia, and weight loss. Approximately one-half of patients cannot tolerate 1 gram as a single dose.

Nervous system side effects

Nervous system side effects have included psychotic disturbances, mental depression, drowsiness, dizziness, restlessness, headache, peripheral neuritis, and a pellagra-like syndrome. Concomitant pyridoxine has been recommended to prevent or relieve neurotoxic effects.

Ocular side effects

Ocular side effects have rarely included optic neuritis, diplopia, and blurred vision.

Hepatic side effects

Hepatic side effects have included transient increases in serum bilirubin, SGOT, SGPT, and hepatitis with or without jaundice.

Hypersensitivity side effects

Hypersensitivity reactions have rarely included rash, photosensitivity, thrombocytopenia, and purpura.

Metabolic side effects

Metabolic side effects have included hypoglycemia.

Genitourinary side effects

Genitourinary side effects have included gynecomastia and impotence.

Dermatologic side effects

Dermatologic side effects have included rash and acne.

Hematologic side effects

Hematologic side effects have included thrombocytopenia and purpura.

Cardiovascular side effects

Cardiovascular side effects have included postural hypotension.

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