Ethionamide Side Effects
Some side effects of ethionamide may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to ethionamide: oral tablet
Along with its needed effects, ethionamide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking ethionamide:Less common
- Clumsiness or unsteadiness
- mental depression
- mood or other mental changes
- numbness, tingling, burning, or pain in hands and feet
- yellow eyes or skin
- Blurred vision or loss of vision, with or without eye pain
- changes in menstrual periods
- decreased sexual ability (in males)
- difficulty in concentrating
- dry, puffy skin
- faster heartbeat
- increased hunger
- skin rash
- swelling of front part of neck
- weight gain
Some side effects of ethionamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Dizziness (especially when getting up from a lying or sitting position)
- loss of appetite
- metallic taste
- nausea or vomiting
- sore mouth
- Enlargement of the breasts (in males)
For Healthcare Professionals
Applies to ethionamide: oral tablet
Gastrointestinal side effects are the most common side effects of ethionamide and may be dose-related. They have included nausea, vomiting, diarrhea, abdominal pain excessive salivation, metallic taste, stomatitis, anorexia, and weight loss. Approximately one-half of patients cannot tolerate 1 gram as a single dose.
Nervous system side effects have included psychotic disturbances, mental depression, drowsiness, dizziness, restlessness, headache, peripheral neuritis, and a pellagra-like syndrome. Concomitant pyridoxine has been recommended to prevent or relieve neurotoxic effects.
Ocular side effects have rarely included optic neuritis, diplopia, and blurred vision.
Hepatic side effects have included transient increases in serum bilirubin, SGOT, SGPT, and hepatitis with or without jaundice.
Hypersensitivity reactions have rarely included rash, photosensitivity, thrombocytopenia, and purpura.
Metabolic side effects have included hypoglycemia and hypothyroidism.
Genitourinary side effects have included gynecomastia and impotence.
Dermatologic side effects have included rash and acne.
Hematologic side effects have included thrombocytopenia and purpura.
Cardiovascular side effects have included postural hypotension.
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