Ethinyl estradiol / etonogestrel Side Effects
Not all side effects for ethinyl estradiol / etonogestrel may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to ethinyl estradiol / etonogestrel: vaginal insert extended release
The risk of serious adverse effects is unlikely for most women using the etonogestrel and ethinyl estradiol vaginal ring. However, oral combination hormonal contraceptives have been associated with unwanted effects which may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking ethinyl estradiol / etonogestrel:Incidence not determined
- Abdominal fullness
- abdominal pain or tenderness usually after eating a meal
- blurred vision
- changes in skin color
- chest pain or discomfort
- gaseous abdominal pain
- inability to speak
- numbness of hands
- pain or discomfort in arms, jaw, back or neck
- pains in chest, groin, or legs, especially calves of legs
- pounding in the ears
- prominent superficial veins over affected area with tenderness and warmth
- recurrent fever
- severe headaches of sudden onset
- shortness of breath
- slow or fast heartbeat
- sudden loss of coordination
- sudden onset of slurred speech
- sudden vision changes
- sudden and severe weakness in arm and/or leg on one side
- swelling of foot or leg on one side of the body
- temporary blindness
- vomiting or vomiting of blood
- yellow eyes or skin
Get emergency help immediately if any of the following symptoms of overdose occur while taking ethinyl estradiol / etonogestrel:
- Menstrual changes
- vaginal bleeding
Some side effects of ethinyl estradiol / etonogestrel may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More Common
- itching of the vagina or genital area
- pain during sexual intercourse
- pain or tenderness around eyes and cheekbones
- sore throat
- stuffy or runny nose
- thick, white vaginal discharge with no odor or with a mild odor
- tightness of chest or wheezing
- weight gain
- false or unusual sense of well-being
- mental depression
- quick to react or overreact emotionally
- rapidly changing moods, mild feeling of sadness or discouragement that come and go
- Absent, missed, or irregular menstrual periods
- bloody vaginal discharge
- brown, blotchy spots on exposed skin
- clay-colored stools
- contact lenses intolerance
- dark urine
- decreased amount or quality of milk
- dry mouth
- dry skin
- fruit-like or unpleasant breath odor
- increased hunger
- increased thirst
- increased urination
- loss of appetite
- medium to heavy, irregular vaginal bleeding between regular monthly periods, which may require the use of a pad or a tampon
- soreness, swelling, or discharge from the breast or breasts
- trouble getting pregnant
- unexplained weight loss
- unusual tiredness or weakness
For Healthcare Professionals
Applies to ethinyl estradiol / etonogestrel: vaginal ring
Genitourinary side effects reported by 5% to 14% of women include vaginitis and leukorrhea. The most common events leading to discontinuation in 1% to 2.5% of women include foreign body sensation, coital problems, and device expulsion. Vaginal/cervical erosion or ulceration in women using ethinyl estradiol and etonogestrel vaginal ring has been rarely reported. In some cases, the ring adhered to vaginal tissue, necessitating removal by a healthcare provider. There have been rare reports of inadvertent insertions of ethinyl estradiol and etonogestrel vaginal ring into the urinary bladder, which required cystoscopic removal. Healthcare providers should assess for ring insertion into the urinary bladder in ethinyl estradiol and etonogestrel vaginal ring users who present with persistent urinary symptoms and are unable to locate the ring.
Respiratory side effects reported by 5% to 14% of women include upper respiratory tract infection and sinusitis.
Gastrointestinal side effects reported by 5% to 14% of women include nausea. Combination contraceptives have been associated with reports of abdominal cramping, bloating, and vomiting.
General side effects reported by 5% to 14% of women include weight gain and headache. The most common adverse effect leading to discontinuation in 1% to 2.5% of women was emotional lability and weight gain.
Hematologic side effects associated with the use of combination hormonal contraceptives include thromboembolic disorders.
Cardiovascular side effects reported with the use of combination hormonal contraceptives include hypertension and myocardial infarction.
Hepatic side effects reported with the use of combination hormonal contraceptives include hepatic adenomas and benign liver tumors.
Ocular side effects reported with the use of combination hormonal contraceptives include retinal thrombosis, changes in corneal curvature (steepening), and intolerance to contact lenses.
More about ethinyl estradiol/etonogestrel
- Etonogestrel/ethinyl estradiol ring
- Ethinyl estradiol and etonogestrel vaginal ring
- Ethinyl estradiol and etonogestrel Vaginal (Advanced Reading)
- Other brands: NuvaRing
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