Estradiol and levonorgestrel Side Effects
Please note - some side effects for Estradiol and levonorgestrel may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
Side Effects by Body System - for Healthcare Professionals
Applies to: transdermal film, extended release
Cardiovascular side effects have included myocardial infarction and stroke as well as venous thrombosis and pulmonary embolism. Hypertension has been reported in 3.3 % of patients in one study.
Dermatologic side effects have included application site reactions (40.6%) and rash (2.4%).
Gastrointestinal side effects have included flatulence (3.8%).
Genitourinary side effects have included urinary tract infection (3.3%), vaginal bleeding (36.8%), breast pain (18.9%), and vaginitis (1.9%).
Musculoskeletal side effects have included back pain (6.1%) and arthralgia (4.2%).
Oncologic side effects have included endometrial and breast cancer.
Psychiatric side effects have included depression (5.7%) and headache (5.2%).
Respiratory side effects have included bronchitis (4.2%), sinusitis (3.8%), and upper respiratory infection (13.2%).
Metabolic side effects have included edema (3.8%) and weight gain (2.8%)
General side effects have included infection (3.3%), abdominal pain (4.2%), flu syndrome (4.7%), pain (5.2%), and accidental injury (3.3%).
Hypersensitivity side effects have included urticaria, angioedema, and anaphylactoid/anaphylactic reactions.Top
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