Estradiol and levonorgestrel Side Effects

Please note - some side effects for Estradiol and levonorgestrel may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects by Body System - for Healthcare Professionals

Applies to: transdermal film, extended release

Cardiovascular

Cardiovascular side effects have included myocardial infarction and stroke as well as venous thrombosis and pulmonary embolism. Hypertension has been reported in 3.3 % of patients in one study.

Dermatologic

Dermatologic side effects have included application site reactions (40.6%) and rash (2.4%).

Gastrointestinal

Gastrointestinal side effects have included flatulence (3.8%).

Genitourinary

Genitourinary side effects have included urinary tract infection (3.3%), vaginal bleeding (36.8%), breast pain (18.9%), and vaginitis (1.9%).

Musculoskeletal

Musculoskeletal side effects have included back pain (6.1%) and arthralgia (4.2%).

Oncologic

Oncologic side effects have included endometrial and breast cancer.

Psychiatric

Psychiatric side effects have included depression (5.7%) and headache (5.2%).

Respiratory

Respiratory side effects have included bronchitis (4.2%), sinusitis (3.8%), and upper respiratory infection (13.2%).

Metabolic

Metabolic side effects have included edema (3.8%) and weight gain (2.8%)

General

General side effects have included infection (3.3%), abdominal pain (4.2%), flu syndrome (4.7%), pain (5.2%), and accidental injury (3.3%).

Hypersensitivity

Hypersensitivity side effects have included urticaria, angioedema, and anaphylactoid/anaphylactic reactions.

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