Esomeprazole and naproxen Side Effects
Please note - some side effects for Esomeprazole and naproxen may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
Side Effects by Body System - for Healthcare Professionals
Applies to: oral delayed release tablet
Gastrointestinal side effects have included erosive gastritis, dyspepsia, gastritis, diarrhea, gastric ulcer, upper abdominal pain, nausea, hiatus hernia, abdominal distension, flatulence, esophagitis, constipation, abdominal pain, erosive duodenitis, lower abdominal pain, duodenitis, hemorrhagic gastritis, gastroesophageal reflux disease, duodenal ulcer, and erosive esophagitis. Postmarketing reports have included gastrointestinal bleeding and/or perforation, hematemesis, pancreatitis, vomiting, colitis, exacerbation of inflammatory bowel disease (ulcerative colitis, Crohn's disease), nonpeptic gastrointestinal ulceration, ulcerative stomatitis, esophagitis, microscopic colitis, and peptic ulceration.
Cardiovascular side effects have included congestive heart failure, vasculitis, hypertension, pulmonary edema, and peripheral edema.
Respiratory side effects have included upper respiratory tract infection, bronchitis, bronchospasm, sinusitis, cough and nasopharyngitis. Postmarketing reports have included eosinophilic pneumonitis and asthma.
Musculoskeletal side effects have included muscle spasm (tetany), arthralgia, aggravation of arthritis, arthropathy, cramps, fibromyalgia syndrome, hernia, hypertonia, polymyalgia rheumatica, and back pain. Myalgia and bone fracture have also been reported.
Nervous system side effects have included headache, dizziness, and dysgeusia. Postmarketing reports have included inability to concentrate, depression, dream abnormalities, insomnia, malaise, myalgia, muscle weakness, aseptic meningitis, cognitive dysfunction, hepatic encephalopathy, taste disturbance, and seizures.
Hepatic side effects have included jaundice, abnormal liver function tests, and hepatitis (some cases have been fatal).
Hematologic side effects have included eosinophilia, leucopenia, melena, thrombocytopenia, agranulocytosis, granulocytopenia, pancytopenia, hemolytic anemia, and aplastic anemia.
Dermatologic side effects have included alopecia, urticaria, skin rashes, hyperhidrosis, toxic epidermal necrolysis, erythema multiforme, erythema nodosum, fixed drug eruption, lichen planus, pustular reaction, systemic lupus erythematosus, bullous reactions, including Stevens-Johnson syndrome, photosensitive dermatitis, photosensitivity reactions, including rare cases resembling porphyria cutanea tarda (pseudoporphyria) or epidermolysis bullosa, and toxic epidermal necrolysis (some fatal).
Hypersensitivity side effects have included anaphylactoid reactions, shock, and angioneurotic edema.
Endocrine side effects have included hyperglycemia and hypoglycemia.
Ocular side effects have included blurred vision, corneal opacity, papillitis, retrobulbar optic neuritis, and papilledema.
Renal side effects have included glomerular nephritis, hematuria, hyperkalemia, interstitial nephritis, nephrotic syndrome, renal disease, renal failure, raised serum creatinine, and renal papillary necrosis.
Genitourinary side effects have included infertility, gynecomastia, and menstrual disorders.
General side effects have included pyrexia (chills and fever).
Psychiatric side effects have included aggression, agitation, depression, and hallucination.
FDA warns that prescription proton pump inhibitor (PPI) drugs may cause low serum magnesium levels (hypomagnesemia) if taken for prolonged periods of time (in most cases, longer than one year).Top
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.