Eplerenone Side Effects
Some side effects of eplerenone may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to eplerenone: oral tablet
Along with its needed effects, eplerenone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking eplerenone:Less common
- Excess of cholesterol in the blood
- excess of triglycerides in the blood
- Abdominal or stomach pain
- arm, back, or jaw pain
- chest pain or discomfort
- chest tightness or heaviness
- difficulty with breathing
- fast or irregular heartbeat
- irregular heartbeat
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- numbness or tingling in the hands, feet, or lips
- pain or discomfort in the arms, jaw, back, or neck
- shortness of breath
- weakness or heaviness of the legs
Some side effects of eplerenone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less common
- Abnormal vaginal bleeding
- breast pain
- cloudy urine
- general feeling of discomfort or illness
- joint pain
- loss of appetite
- muscle aches and pains
- swelling of the breasts or breast soreness in both females and males
- unusual tiredness or weakness
For Healthcare Professionals
Applies to eplerenone: oral tablet
Metabolic side effects have included hyperkalemia (>5.5 mEq/L). Hyperkalemia was observed in 2.6% of patients with creatinine clearance greater than 100 mL/min, in 5.6% of patients with creatinine clearance of 70 to 100 mL/min, and in 10.4% of patients with creatinine clearance less than 70 mL/min. The principal risk of eplerenone is hyperkalemia, which can result in serious, sometimes fatal arrhythmias.
Other metabolic side effects have included hypercholesterolemia and hypertriglyceridemia in 1% of patients.
Nervous system side effects have included dizziness (3%) and headache. In a pharmacokinetic study, headache was reported in 14% to 63% of patients.
General side effects have included fatigue and influenza-like symptoms.
Renal side effects have included albuminuria in 1% of patients.
Respiratory side effects have included cough in 2% of patients.
Gastrointestinal side effects have included diarrhea in 2% and abdominal pain in 1% of patients.
Endocrine side effects have included gynecomastia (up to 1%) and mastodynia (up to 1.3%) of male patients. Abnormal vaginal bleeding was reported in 2.5% of female patients.
Hepatic side effects have included increases in serum alanine aminotransferase (ALT) and gamma glutamyl transpeptidase (GGT).
More eplerenone resources
- eplerenone MedFacts Consumer Leaflet (Wolters Kluwer)
- eplerenone Concise Consumer Information (Cerner Multum)
- eplerenone Advanced Consumer (Micromedex) - Includes Dosage Information
- Eplerenone Prescribing Information (FDA)
- Eplerenone Professional Patient Advice (Wolters Kluwer)
- Eplerenone Monograph (AHFS DI)
- Inspra Prescribing Information (FDA)
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