Entereg Side Effects

Generic name: alvimopan

Medically reviewed by Drugs.com. Last updated on Mar 18, 2023.

Note: This document contains side effect information about alvimopan. Some dosage forms listed on this page may not apply to the brand name Entereg.

Applies to alvimopan: oral capsule.

Warning

Oral route (Capsule)

There was a greater incidence of myocardial infarction in alvimopan-treated patients compared to placebo-treated patients in a 12-month clinical trial, although a causal relationship has not been established. In short-term trials with Alvimopan, no increased risk of myocardial infarction was observed. Because of the potential risk of myocardial infarction with long-term use, alvimopan is available only through a restricted program for short-term use (15 doses) under a Risk Evaluation and Mitigation Strategy (REMS) called the Alvimopan REMS Program.

Serious side effects of Entereg

Along with its needed effects, alvimopan (the active ingredient contained in Entereg) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking alvimopan:

More common

Acid or sour stomach
belching
bloated
convulsions
decreased urine
difficulty having a bowel movement (stool)
dry mouth
excess air or gas in stomach or intestines
full feeling
heartburn
increased thirst
indigestion
irregular heartbeat
loss of appetite
mood changes
muscle pain or cramps
nausea or vomiting
numbness or tingling in hands, feet, or lips
pale skin
passing gas
shortness of breath
stomach discomfort, upset, or pain
troubled breathing with exertion
unusual bleeding or bruising
unusual tiredness or weakness

Less common

Decrease in frequency of urination
decrease in urine volume
difficulty in passing urine (dribbling)
painful urination

Other side effects of Entereg

Some side effects of alvimopan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: