Emend for Injection Side Effects

Generic Name: fosaprepitant

Note: This page contains information about the side effects of fosaprepitant. Some of the dosage forms included on this document may not apply to the brand name Emend for Injection.

Not all side effects for Emend for Injection may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to fosaprepitant: intravenous powder for solution

In addition to its needed effects, some unwanted effects may be caused by fosaprepitant (the active ingredient contained in Emend for Injection). In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking fosaprepitant, check with your doctor or nurse immediately:

More common
  • Black, tarry stools
  • blurred vision
  • chills
  • confusion
  • cough
  • decreased urination
  • difficult or labored breathing
  • dizziness
  • dry mouth
  • fainting
  • fever
  • increase in heart rate
  • lightheadedness
  • lower back or side pain
  • nervousness
  • pain, swelling, or redness at the injection site
  • painful or difficult urination
  • pale skin
  • pounding in the ears
  • rapid breathing
  • shortness of breath
  • slow or fast heartbeat
  • sore throat
  • sunken eyes
  • tenderness, swelling, warmth, or skin discoloration at the injection site
  • thirst
  • tightness in the chest
  • ulcers, sores, or white spots in mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • wheezing
  • wrinkled skin
Less common
  • Hard lump at the injection site
Rare
  • Blood in the urine
  • changes in patterns and rhythms of speech
  • changes in skin color
  • chest pain or discomfort
  • coma
  • convulsions
  • fast, slow, irregular, pounding, or racing heartbeat or pulse
  • general feeling of discomfort or illness
  • headache
  • increased sweating
  • increased thirst
  • lightheadedness, dizziness, or fainting
  • muscle pain or cramps
  • nausea or vomiting
  • pain, tenderness, or swelling of the foot or leg
  • slurred speech
  • swelling
  • swelling of the face, ankles, or hands
  • trouble with speaking
  • troubled breathing with exertion
  • wheezing
Incidence not known
  • Difficulty with swallowing
  • hives or welts
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin

Some of the side effects that can occur with fosaprepitant may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Acid or sour stomach
  • belching
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • continuing ringing or buzzing or other unexplained noise in ears
  • diarrhea
  • difficulty having a bowel movement (stool)
  • dizziness
  • feeling of indigestion
  • hair loss or thinning of the hair
  • hearing loss
  • hiccups
  • indigestion
  • lack or loss of strength
  • loss of appetite
  • pain in the chest below the breastbone
  • stomach discomfort, upset, or pain
  • swelling or inflammation of the mouth
  • weight loss
Less common
  • Feeling of warmth
  • pain or discomfort in chest, upper stomach, or throat
  • redness of the face, neck, arms, and occasionally, upper chest
  • sudden sweating
  • unusually warm skin
Rare
  • Abdominal or stomach distension or pain
  • abnormal dreams
  • blemishes on the skin
  • bumps on the skin
  • burning, dry, or itching eyes
  • change in taste
  • change in walking and balance
  • clumsiness or unsteadiness
  • confusion about identity, place, and time
  • difficulty with moving
  • discharge, excessive tearing
  • excess air or gas in the stomach
  • extreme thirst
  • false or unusual sense of well-being
  • flushed, dry skin
  • frequent urination
  • fruit-like breath odor
  • full feeling
  • heartburn
  • increased hunger
  • increased sensitivity of the skin to sunlight
  • increased urination
  • increased volume of pale, dilute urine
  • joint pain
  • muscle aching or cramping
  • muscle stiffness or weakness
  • oily skin
  • passing gas
  • pimples
  • redness or other discoloration of the skin
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • severe constipation
  • severe sunburn
  • sleepiness
  • sleeplessness
  • sweating
  • swollen joints
  • trouble performing routine tasks
  • trouble sleeping
  • unable to sleep
  • unexplained weight loss
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
  • weight gain
  • white patches in the mouth or throat or on the tongue
  • white patches with diaper rash

For Healthcare Professionals

Applies to fosaprepitant: intravenous powder for injection

General

In general, because fosaprepitant (the active ingredient contained in Emend for Injection) injection is converted to aprepitant, those adverse experiences associated with aprepitant might also be expected to occur with fosaprepitant for injection. General side effects including asthenia/fatigue (17.8%), dizziness (3.4% to 6.6%), dehydration (5.9%), abdominal pain (4.6%), fever (2.9%), mucous membrane disorder (2.6%) have been reported with the use of aprepitant as a part of a regimen that also included ondansetron and dexamethasone which was given along with moderately or highly emetogenic cancer chemotherapy. Diaphoresis, edema, flushing, malaise, pelvic pain, septic shock, and upper respiratory infection have also been reported.

Local

Local side effects have included infusion site reactions of erythema, pruritus, induration, pain and thrombophlebitis.

Nervous system

Nervous system side effects including headache (2.3%) have been reported with the use of fosaprepitant (the active ingredient contained in Emend for Injection) injection. Nervous system side effects including headache (8.5% to 16.4%) and insomnia (2.9%) have been reported with the use of aprepitant as a part of a regimen that also included ondansetron and dexamethasone which was given along with highly emetogenic cancer chemotherapy. Peripheral neuropathy and sensory neuropathy have also been reported.

Dermatologic

Dermatologic side effects including alopecia (24%) and rash have been reported with the use of aprepitant as a part of a regimen that also included ondansetron and dexamethasone which was given along with moderately or highly emetogenic cancer chemotherapy. Postmarketing side effects reported include pruritus, rash, urticaria, and rarely Stevens-Johnson syndrome/toxic epidermal necrolysis.

Gastrointestinal

Gastrointestinal side effects including nausea (7.1% to 12.7%), constipation (10.3% to 12.3%), diarrhea (5.5% to 10.3%), dyspepsia (8.4%), vomiting (7.5%), stomatitis (5.3%), heartburn (5.3%), gastritis (4.2%), and epigastric discomfort (4.0%) have been reported with the use of aprepitant as a part of a regimen with ondansetron and dexamethasone which was given along with moderately or highly emetogenic cancer chemotherapy. Acid reflux, deglutination, disorder, dysgeusia, dysphagia, flatulence, obstipation, increased salivation, and taste disturbance have also been reported.

Respiratory

Respiratory side effects including hiccups (10.8%) have been reported with the use of aprepitant as a part of a regimen that also included ondansetron and dexamethasone which was given along with moderately or highly emetogenic cancer chemotherapy. Cough, dyspnea, pneumonitis, respiratory insufficiency, lower respiratory infection, nasal secretion, pharyngitis, pharyngolaryngeal pain, and vocal disturbance have also been reported.

Other

Other side effects including anorexia (4.3% to 10.1%) and tinnitus (3.7%) have been reported with the use of aprepitant as a part of a regimen that also included ondansetron and dexamethasone which was given along with moderately or highly emetogenic cancer chemotherapy.

Oncologic

Oncologic side effects including malignant neoplasm and non-small cell lung carcinoma have been reported with the use of aprepitant as a part of a regimen that also included ondansetron and dexamethasone which was given along with highly emetogenic cancer chemotherapy.

Thyroid follicular cell adenomas and carcinomas in male rats and increased incidences of hepatocellular adenoma and thyroid follicular adenoma in female rats have been reported. Aprepitant has also been reported to cause skin fibrosarcomas in male mice.

Hematologic

Hematologic side effects including neutropenia have been reported with the use of aprepitant as a part of a regimen that also included ondansetron and dexamethasone which was given along with highly emetogenic cancer chemotherapy. Anemia, febrile neutropenia, and thrombocytopenia have also been reported.

Cardiovascular

Cardiovascular side effects including deep vein thrombosis, hypertension, hypotension, myocardial infarction, pulmonary embolism, and tachycardia have been reported with the use of aprepitant as a part of a regimen that also included ondansetron and dexamethasone which was given along with highly emetogenic cancer chemotherapy.

Metabolic

Metabolic side effects including diabetes mellitus have been reported with the use of aprepitant as a part of a regimen that also included ondansetron and dexamethasone which was given along with highly emetogenic cancer chemotherapy. Decreased appetite, hypokalemia, and weight loss have also been reported.

Musculoskeletal

Musculoskeletal side effects including muscular weakness, musculoskeletal pain, and myalgia have been reported with the use of aprepitant as a part of a regimen that also included ondansetron and dexamethasone which was given along with highly emetogenic cancer chemotherapy.

Psychiatric

Psychiatric side effects including anxiety disorder, confusion, and depression have been reported with the use of aprepitant as a part of a regimen that also included ondansetron and dexamethasone which was given along with highly emetogenic cancer chemotherapy.

Genitourinary

Genitourinary side effects including dysuria and renal insufficiency have been reported with the use of aprepitant as a part of a regimen that also included ondansetron and dexamethasone which was given along with highly emetogenic cancer chemotherapy.

Hypersensitivity

Hypersensitivity side effects have included immediate flushing, erythema, and dyspnea during infusion of fosaprepitant (the active ingredient contained in Emend for Injection) These hypersensitivity reactions have generally responded to discontinuation of the infusion and administration of appropriate therapy. It is not recommended to reinitiate the infusion in patients who experience hypersensitivity reactions.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide
(web5)