Efidac-24 Chlorpheniramine Side Effects

Generic Name: chlorpheniramine maleate, dexchlorpheniramine maleate

Please note - some side effects for Efidac-24 Chlorpheniramine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects by Body System - for Healthcare Professionals

Applies to: compounding powder; injectable solution; oral capsule, extended release; oral liquid; oral suspension, extended release; oral syrup; oral tablet; oral tablet, chewable; oral tablet, extended release

Nervous system

Central nervous system side effects have included depression resulting in drowsiness in 75% or more of treated patients. Dyskinesias have rarely been reported following chronic use of chlorpheniramine.

Nearly all patients treated with chlorpheniramine experience drowsiness. This drowsiness may subside in some patients with extended use.

Few cases of dyskinesias and tremors, often of the face, have been reported in patients whose chronic use of chlorpheniramine extended over a period of 3 to 10 years. Some of these cases were only partially relieved by discontinuation of the drug. Haloperidol was successful in relieving symptoms.

Gastrointestinal

Gastrointestinal side effects have included dry mouth and constipation in up to one-third of treated patients.

Cardiovascular

Cardiovascular side effects have included hypotension, tachycardia, and palpitations.

Ocular

Ocular side effects of chlorpheniramine may include blurred vision, diplopia, and dry eyes due to anticholinergic effects.

Genitourinary

Genitourinary side effects have included dysuria, urinary hesitancy, and a decreased urine flow. In rare cases, the anticholinergic effect of chlorpheniramine has precipitated acute urinary retention.

Hematologic

Hematologic side effects have included bone marrow suppression, thrombocytopenia, and aplastic anemia.

A fatal case of agranulocytosis has been reported in a patient taking chlorpheniramine, pseudoephedrine, acetaminophen, dextromethorphan, phenylpropanolamine, and aspirin. Chlorpheniramine was felt to be the cause.

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