Dynacirc Side Effects

Generic Name: isradipine

Note: This page contains information about the side effects of isradipine. Some of the dosage forms included on this document may not apply to the brand name Dynacirc.

Not all side effects for Dynacirc may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to isradipine: oral capsule, oral tablet, oral tablet extended release

In addition to its needed effects, some unwanted effects may be caused by isradipine (the active ingredient contained in Dynacirc). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking isradipine:

More common
  • Bloating or swelling of face, arms, hands, lower legs, or feet
  • tingling of hands or feet
  • unusual weight gain or loss
Less common
  • Chest pain
  • difficult or labored breathing
  • dizziness
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling of warmth
  • full or bloated feeling
  • nausea
  • pressure in the stomach
  • redness of the face, neck, arms and occasionally, upper chest
  • shortness of breath
  • swelling of abdominal or stomach area
  • tightness in chest
  • unusual tiredness or weakness
  • vomiting
  • wheezing

If any of the following symptoms of overdose occur while taking isradipine, get emergency help immediately:

Symptoms of Overdose
  • Blurred vision
  • confusion
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • flushing
  • sweating

Some of the side effects that can occur with isradipine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Headache
Less common
  • Diarrhea
  • difficulty having a bowel movement (stool)
  • rash
  • stomach soreness or discomfort

For Healthcare Professionals

Applies to isradipine: oral capsule, oral tablet extended release

General

Isradipine (the active ingredient contained in Dynacirc) is generally well-tolerated. Most side effects occurred as commonly as with placebo in placebo-controlled trials, except for flushing, headache, and palpitations.

Cardiovascular

Cardiovascular side effects are among the most common, and are related to the vasodilatory properties of isradipine (the active ingredient contained in Dynacirc) Peripheral edema and flushing are reported in 3% to 14% of patients, being more common at higher doses. Dizziness occurs in 3% to 8% of patients.

Palpitations or a greater awareness of heart beats is reported in 1% to 5% of patients. Flushing and palpitations are more likely with dosages greater than 5 mg daily; women have reported flushing more than men. Edema was reported in up to 22% of patients in one study (mean dose was 5.9 mg TID). In large studies, the incidence of edema is less than 3%, and appeared to be more likely in patients greater than 60 years of age.

Isradipine does not appear to adversely affect plasma lipids.

Nervous system

Headache was reported in up to 16% of patients in one study, although the mean dose was 5.9 mg three times daily to treat angina pectoris. Headache is more likely with dosages greater than 5 mg daily. Visual disturbances are reported in less than 2% of patients. Sleep disturbances are reported in 0.1% of patients.

Nervous system side effects are probably related to the vasodilatory effects of isradipine. Headache is reported in 9% to 30% of patients and fatigue is reported in 7% of patients.

Gastrointestinal

Anorexia, nausea, vomiting, and diarrhea are reported in less than 4% of patients.

Gastrointestinal side effects are unusual, and include constipation in less than 2% of patients.

Respiratory

Respiratory system complaints include dyspnea and cough in 2% of patients.

Musculoskeletal

Musculoskeletal pain is reported in 1% of patients.

Dermatologic

Dermatologic complaints of "disturbed skin sensation" are reported in less than 4% of patients.

Hypersensitivity

Hypersensitivity reactions to isradipine (the active ingredient contained in Dynacirc) are rare. Pruritus, urticaria, and angioedema have been reported.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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