Duohist DH Side Effects

Generic Name: chlorpheniramine / dihydrocodeine / phenylephrine

Note: This document contains side effect information about chlorpheniramine / dihydrocodeine / phenylephrine. Some of the dosage forms listed on this page may not apply to the brand name Duohist DH.

Some side effects of Duohist DH may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to chlorpheniramine / dihydrocodeine / phenylephrine: liquid, syrup

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; dry mouth, throat, or nose; excitement; nausea; stomach upset; thickening or mucus in nose or throat.

Seek medical attention right away if any of these SEVERE side effects occur while taking chlorpheniramine / dihydrocodeine / phenylephrine:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; fast or irregular heartbeat; flushing or redness of face.

For Healthcare Professionals

Applies to chlorpheniramine / dihydrocodeine / phenylephrine: oral liquid, oral syrup

General

General side effects including light-headedness, dizziness, drowsiness, headache, fatigue, and sedation have been among the most frequently reported with opioid use. Confusion, abdominal pain, lassitude, giddiness, increased irritability or excitement (especially in children) have been reported. Hallucinations, severe narcosis, and vivid dreams have been reported rarely.

Gastrointestinal

Gastrointestinal side effects including nausea, vomiting, and constipation have been among the most frequently reported with opioid use. Diarrhea, dry mouth, indigestion, anorexia, spasm of biliary tract have been reported.

Dermatologic

Dermatologic side effects including sweating, pruritus, and skin reactions have been among the most frequently reported with opioid use. Flushing has been reported.

Other

Symptoms of dihydrocodeine withdrawal consist of irritability, restlessness, insomnia, diaphoresis, anxiety, and palpitations.

Other side effects of dihydrocodeine have included psychological dependence, physical dependence, and tolerance have been reported to develop upon repeated administration.

Renal

Renal side effects including granulomatous interstitial nephritis and acute renal failure have been reported rarely during dihydrocodeine administration.

Cardiovascular

Cardiovascular side effects including orthostatic hypotension and cardiac palpitations have been reported.

Respiratory

Respiratory side effects including respiratory depression have been reported.

Ocular

Ocular side effects including miosis and blurred vision have been reported.

Genitourinary

Genitourinary side effects including urinary retention have been reported.

Hypersensitivity

Hypersensitivity side effects including anaphylactoid reactions have been reported rarely.

More about Duohist DH (chlorpheniramine / dihydrocodeine / phenylephrine)

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Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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