Drospirenone / ethinyl estradiol / levomefolate calcium Side Effects

Not all side effects for drospirenone / ethinyl estradiol / levomefolate calcium may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to drospirenone / ethinyl estradiol / levomefolate calcium: oral tablet

In addition to its needed effects, some unwanted effects may be caused by drospirenone / ethinyl estradiol / levomefolate calcium. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking drospirenone / ethinyl estradiol / levomefolate calcium:

More common
  • Breast pain or tenderness
  • headache, severe and throbbing
  • heavy non-menstrual vaginal bleeding
  • irregular menstrual periods
  • nausea
  • normal menstrual bleeding occurring earlier, possibly lasting longer than expected
Less common
  • Longer or heavier menstrual periods
  • unusual tiredness or weakness
  • vomiting
Incidence not known
  • Abdominal or stomach pain
  • chills
  • clay-colored stools
  • dark urine
  • difficulty with breathing
  • dizziness
  • fever
  • headache
  • itching
  • loss of appetite
  • pain in the chest, groin, or legs, especially the calves
  • rash
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • sudden, unexplained shortness of breath
  • unpleasant breath odor
  • unusual tiredness or weakness
  • vision changes
  • vomiting of blood
  • yellow eyes or skin

Some of the side effects that can occur with drospirenone / ethinyl estradiol / levomefolate calcium may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Crying
  • decreased interest in sexual intercourse
  • delusions of persecution, mistrust, suspiciousness, and/or combativeness
  • false or unusual sense of well-being
  • inability to have or keep an erection
  • irritability
  • loss in sexual ability, desire, drive, or performance
  • mental depression
  • quick to react or overreact emotionally
  • rapidly changing moods
  • weight gain

For Healthcare Professionals

Applies to drospirenone / ethinyl estradiol / levomefolate calcium: oral tablet

Cardiovascular

Cardiovascular side effects have included hypertension, arterial or deep venous thrombotic events, strokes, and myocardial infarctions.

Genitourinary

Genitourinary side effects have included breast tenderness, decreased libido, unscheduled (breakthrough or intracyclic) bleeding and spotting.

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, and inflammatory bowel disease.

Hepatic

Hepatic side effects have included jaundice, cholestasis and hepatic adenomas.

Metabolic

Metabolic side effects have included gallbladder disease, liver function disturbances, liver tumors, hyperkalemia, hypertriglyceridemia, changes in glucose tolerance, and effect on peripheral insulin resistance (including diabetes mellitus).

Nervous system

Nervous system side effects have included an increase in frequency or severity of migraine headaches.

Ocular

Ocular side effects have included loss of vision, proptosis, diplopia, papilledema, or retinal vascular lesions.

Psychiatric

Psychiatric side effects have included irritability, depression and affect lability.

Oncologic

Oncologic side effects have included carcinoma of the breasts and reproductive organs.

Musculoskeletal

Musculoskeletal side effects have included systemic lupus erythematosus.

Dermatologic

Dermatologic side effects have included chloasma, angioedema, erythema nodosum, and erythema multiforme.

Hypersensitivity

Hypersensitivity side effects have included anaphylactic reaction.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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