Dorzolamide Side Effects

Please note - some side effects for Dorzolamide may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of Dorzolamide - for the Consumer

Dorzolamide Drops

Applies to: eye drops

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Dorzolamide Drops:

Bitter taste in mouth; blurred vision; burning and stinging upon instillation; dryness of eyes; eye sensitivity to sunlight; redness of the eyes; tearing.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); burning, numbness, or tingling; dizziness; eye pain; irritated eyelids; red, swollen, blistered, or peeling skin; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Side Effects by Body System - for Healthcare Professionals

Applies to: ophthalmic solution

Ocular

Foreign body sensation has been reported due to formation of precipitate on the tip of the dropper bottle, which entered the eye during instillation of the eye drops.

A 76-year-old woman with a 7-year history of open-angle glaucoma developed an abrupt choroidal detachment in the surgically untreated eye following 2 doses of dorzolamide. Systemic medications included verapamil and hydrochlorothiazide. Ocular medications consisted of timolol 0.5% twice daily to both eyes for the past 7 years. This reaction may have been a result of hypotony or an idiosyncratic reaction to the sulfa-containing agent, dorzolamide.

Ocular side effects have included burning and stinging upon instillation which has been reported in approximately 33% of patients receiving dorzolamide ophthalmic drops. Superficial punctate epithelial erosions occurred in approximately 15% of patients. Evidence of local allergic reaction to dorzolamide was present in approximately 10% of patients. Other ocular events seen in 1% to 5% of patients were conjunctivitis, lid reactions, dryness, photophobia, tearing, and blurred vision. Transient myopia, ocular pain, iridocyclitis, and eyelid crusting have been reported rarely. Slight increases in central corneal thickness have been reported in patients with cornea guttata after short-term (1 day) use of dorzolamide. A single case of abrupt choroidal detachment in a surgically untreated eye has been reported.

Other

Approximately 25% of patients have reported a bitter taste following administration.

Hypersensitivity

Hypersensitivity has occurred in approximately 10% of patients. Reactions reported include local ocular reaction, angioedema, pruritus, urticaria, and bronchospasm. Skin rashes and contact dermatitis have also been reported.

Dermatologic

Dermatologic side effects have included skin rashes and throat irritation. Stevens-Johnson syndrome and toxic epidermal necrolysis have been reported rarely.

Nervous system

Nervous system side effects have included headache, asthenia, paresthesia and dizziness.

Gastrointestinal

Gastrointestinal side effects have included bitter taste (25%), nausea (infrequent), throat irritation (<1%), and dry mouth (<1%).

Genitourinary

Genitourinary side effects have included urolithiasis.

Respiratory

Respiratory side effects have included rare reports of bronchospasm, which may be a symptom of hypersensitivity.

Hematologic

Hematologic side effects have included epistaxis.

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