Dipivefrin Side Effects

Please note - some side effects for Dipivefrin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Dipivefrin - for the Consumer

Dipivefrin

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Dipivefrin:

Blurred vision; burning; eye redness; headache; itching; sensitivity to light; stinging.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); decrease in vision; eye pain; fast heartbeat; irregular heartbeat; swelling of the eye or eyelids.

Dipivefrin Side Effects - for the Professional

Dipivefrin

Cardiovascular Effects

Tachycardia, arrhythmias and hypertension have been reported with ocular administration of epinephrine.

Local Effects

  The most frequent side effects reported with Dipivefrin hydrochloride alone were injection in 6.5% of patients and burning and stinging in 6%. Follicular conjunctivitis, mydriasis and allergic reactions to Dipivefrin have been reported infrequently. Epinephrine therapy can lead to adrenochrome deposits in the conjunctiva and cornea.

Side Effects by Body System

Ocular

Ocular side effects have included injection (6.5%), stinging (6%), and burning (6%). Follicular conjunctivitis and mydriasis have been reported rarely. Corneal vascularization or vesicles, eyelid ectropion, papillary conjunctivitis, blepharoconjunctivitis, macular edema, corneal toxicity (dendritic keratitis, punctate keratitis, or epitheliopathy), and blurred vision have also been reported.

Ocular side effects associated with ocular administration of epinephrine have included conjunctival and corneal adrenochrome deposits.

Some long-term studies have reported observations of follicular conjunctivitis in almost all patients with up to 40% classified as severe reactions.

Cardiovascular

Cardiovascular side effects have included slight increases in heart rate and diastolic blood pressure.

Cardiovascular side effects associated with ocular epinephrine have included tachycardia, arrhythmias, and hypertension.

Most placebo-controlled studies have reported mild average increases in heart rate (3 to 4 beats/min--with or without palpitations) or diastolic blood pressure (1 to 5 mm Hg) associated with dipivefrin.

Nervous system

Nervous system side effects have included headache and dizziness.

Hypersensitivity

Hypersensitivity reactions have included bronchospasm associated with a formulation containing bisulfite preservative.

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