Dipivefrin ophthalmic Side Effects

Some side effects of dipivefrin ophthalmic may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to dipivefrin ophthalmic: ophthalmic solution

Stop using dipivefrin and Get emergency medical help if you have any of these signs of an allergic reaction while taking dipivefrin ophthalmic: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• severe stinging or burning in your eyes;

• fast or uneven heart rate; or

• high blood pressure (severe headache, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath).

Less serious side effects of dipivefrin ophthalmic may include:

• burning, stinging, or itching of your eyes;

• blurred vision;

• redness of the eye or eyelid;

• sensitivity to light;

• eye pain; or

• headache.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

For Healthcare Professionals

Applies to dipivefrin ophthalmic: ophthalmic solution

Ocular

Ocular side effects have included injection (6.5%), stinging (6%), and burning (6%). Follicular conjunctivitis and mydriasis have been reported rarely. Corneal vascularization or vesicles, eyelid ectropion, papillary conjunctivitis, blepharoconjunctivitis, macular edema, corneal toxicity (dendritic keratitis, punctate keratitis, or epitheliopathy), and blurred vision have also been reported.

Ocular side effects associated with ocular administration of epinephrine have included conjunctival and corneal adrenochrome deposits.

Some long-term studies have reported observations of follicular conjunctivitis in almost all patients with up to 40% classified as severe reactions.

Cardiovascular

Cardiovascular side effects have included slight increases in heart rate and diastolic blood pressure.

Cardiovascular side effects associated with ocular epinephrine have included tachycardia, arrhythmias, and hypertension.

Most placebo-controlled studies have reported mild average increases in heart rate (3 to 4 beats/min--with or without palpitations) or diastolic blood pressure (1 to 5 mm Hg) associated with dipivefrin.

Nervous system

Nervous system side effects have included headache and dizziness.

Hypersensitivity

Hypersensitivity reactions have included bronchospasm associated with a formulation containing bisulfite preservative.

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