Diphtheria and tetanus toxoids vaccine Side Effects

Please note - some side effects for Diphtheria and tetanus toxoids vaccine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects by Body System - for Healthcare Professionals

Applies to: intramuscular suspension

Hypersensitivity

Hypersensitivity side effects have included Arthus-type reactions, characterized by severe local reactions (generally starting 2 to 8 hours after an injection) may occur, particularly in persons who have received multiple prior boosters. Rarely, an anaphylactic reaction (ie, hives, swelling of the mouth, difficulty breathing, hypotension, or shock) and death have been reported after receiving preparations containing diphtheria and tetanus antigens.

Local

Local side effects have included redness, warmth, edema, induration, with or without tenderness, as well as urticaria, and rash.

Nervous system

Nervous system side effects have included cochlear lesion, brachial plexus neuropathies, paralysis of the radial nerve, paralysis of the recurrent nerve, accommodation paresis, Guillain-Barre syndrome (GBS), and EEG disturbances with encephalopathy.

General

General side effects have included fever less than 39 degrees C (less than 102.2 degrees F).

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