Dimethyl sulfoxide Side Effects

Not all side effects for dimethyl sulfoxide may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to dimethyl sulfoxide: intravesical solution

In addition to its needed effects, some unwanted effects may be caused by dimethyl sulfoxide. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking dimethyl sulfoxide:

  • Nasal congestion
  • shortness of breath or troubled breathing
  • skin rash, hives, or itching
  • swelling of face

Some patients may have some discomfort during the time this medicine is being put into the bladder. However, the discomfort usually becomes less each time the medicine is used.

Dimethyl sulfoxide may cause you to have a garlic-like taste within a few minutes after the medicine is put into the bladder. This effect may last for several hours. It may also cause your breath and skin to have a garlic-like odor, which may last up to 72 hours.

For Healthcare Professionals

Applies to dimethyl sulfoxide: compounding liquid, irrigation solution, topical solution

Dermatologic

Frequency not reported: Odor on skin (may remain for 72 hours)

Gastrointestinal

Frequency not reported: Garlic-like taste (a few minutes after instillation), odor on breath (may remain for 72 hours)

Genitourinary

Frequency not reported: Chemical cystitis

Local

Frequency not reported: Severe discomfort on administration

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