Diltia XT Side Effects

Generic Name: diltiazem

Note: This page contains information about the side effects of diltiazem. Some of the dosage forms included on this document may not apply to the brand name Diltia XT.

Not all side effects for Diltia XT may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to diltiazem: oral capsule extended release, oral capsule extended release 12 hr, oral capsule extended release 24 hr, oral tablet, oral tablet extended release

In addition to its needed effects, some unwanted effects may be caused by diltiazem (the active ingredient contained in Diltia XT). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking diltiazem:

More common
  • Body aches or pain
  • congestion
  • cough
  • dryness or soreness of throat
  • fever
  • hoarseness
  • runny nose
  • tender or swollen glands in neck
  • trouble in swallowing
  • voice changes
Less common
  • Chest pain or discomfort
  • chills
  • diarrhea
  • difficult or labored breathing
  • feeling faint, dizzy, or lightheaded
  • feeling of warmth or heat
  • flushing or redness of skin, especially on face and neck
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • shivering
  • shortness of breath
  • slow or irregular heartbeat
  • sore throat
  • sweating
  • swelling of hands, ankles, feet, or lower legs
  • tightness in chest
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting
  • wheezing
Incidence not known
  • Blistering, peeling, or loosening of skin
  • itching
  • large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • no heart beat
  • red irritated eyes
  • red skin lesions, often with a purple center
  • sores, ulcers, or white spots in mouth or on lips

Some of the side effects that can occur with diltiazem may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Sneezing
  • stuffy nose
Less common
  • Acid or sour stomach
  • belching
  • constipation
  • continuing ringing or buzzing or other unexplained noise in ears
  • degenerative disease of the joint
  • difficulty in moving
  • hearing loss
  • heartburn
  • indigestion
  • lack or loss of strength
  • muscle aching or cramping
  • muscle pains or stiffness
  • pain or tenderness around eyes and cheekbones
  • rash
  • sleeplessness
  • stomach discomfort, upset, or pain
  • swollen joints
  • unable to sleep
Incidence not known
  • Hair loss or thinning of hair

For Healthcare Professionals

Applies to diltiazem: compounding powder, intravenous powder for injection, intravenous solution, oral capsule extended release, oral tablet, oral tablet extended release

General

Diltiazem (the active ingredient contained in Diltia XT) was generally well-tolerated. Serious side effects have been rare during studies; however, patients with impaired ventricular function and cardiac conduction abnormalities have generally been excluded from these studies. Side effects were usually dose-related and of mild to moderate severity.[Ref]

Cardiovascular

Cardiovascular side effects have included asymptomatic hypotension (4.3%), atrioventricular (AV) block (up to 4%), bradycardia (up to 3.6%), first-degree AV block (up to 3.3%), symptomatic hypotension (3.2%), vasodilation (up to 3%), palpitations (up to 2%), and extrasystoles (up to 2%). Angina, angina pectoris, arrhythmia (including junctional rhythm or isorhythmic dissociation), atrial fibrillation, atrial flutter, AV block (second- or third-degree), bundle branch block, sinus bradycardia, bigeminal extrasystole, congestive heart failure, electrocardiogram abnormalities, hypotension, postural hypotension, hypertension, myocardial infarct, myocardial ischemia, sinus pause, sinus node dysfunction, tachycardia, phlebitis, ST elevation, vasodilatation, ventricular arrhythmia, ventricular fibrillation, ventricular tachycardia, and ventricular extrasystoles have been reported in less than 2% of patients. Sinoatrial depression, atrioventricular depression, sinoatrial heart block, and several cases of sinus arrest, atrioventricular dissociation, and junctional bradycardia have been reported. A case of nodal bigeminy progressing to complete heart block has also been reported. Events such as myocardial infarction, which are not readily distinguishable from the natural history of the disease, and asystole have been reported during postmarketing experience.[Ref]

Nodal bigeminy progressing to complete heart block has been reported in one cardiac patient who ingested a large amount of diltiazem in a suicide attempt.[Ref]

Other

Other side effects have included peripheral edema (up to 15%), lower limb edema (up to 8%), pain (up to 6%), infection (up to 6%), asthenia/fatigue (up to 4.8%), edema (up to 4.6%), influenza syndrome (up to 2.3%), and abdominal enlargement (up to 2%). Increased weight, fever, chest pain, malaise, flushing, pallor, abdominal pain, neck pain, ear pain, otitis media, accidental injury, and unevaluable reaction have been reported in less than 2% of patients.

Nervous system

Nervous system side effects have included dizziness (up to 10%) and headache (up to 8.9%). Amnesia, abnormal thinking, gait abnormality, hallucinations, insomnia, neuropathy, paresthesia, somnolence, syncope, tinnitus, vertigo, hypertonia, and tremor have been reported in less than 2% of patients. Dysosmia, dysgeusia, sensory loss, at least one case of acute Parkinsonism, and at least 2 cases of hyperactive symptoms or akathisia have been reported. Myoclonus has also been reported. Extrapyramidal symptoms have been reported during postmarketing experience.[Ref]

A 62-year-old man with diabetes mellitus, congestive heart failure, and aortic stenosis developed uncontrollable hyperactivity within 24 hours after starting diltiazem. The akathisia was unresponsive to antihistamines and sedatives, and only resolved after discontinuation of diltiazem. A rechallenge was positive.[Ref]

Respiratory

Respiratory side effects have included rhinitis (up to 9.6%), dyspnea (up to 6%), pharyngitis (up to 6%), bronchitis (up to 4%), increased cough (up to 3%), sinusitis (2%), and sinus congestion (up to 2%). Epistaxis, nasal congestion, respiratory distress, and respiratory disorder have been reported in less than 2% of patients. At least one case of eosinophilic pleural effusion that resolved following discontinuation of diltiazem (the active ingredient contained in Diltia XT) has been reported.[Ref]

Gastrointestinal

Gastrointestinal side effects have included dyspepsia (up to 6%), constipation (up to 3.6%), nausea (up to 2.2%), vomiting (up to 2%), and diarrhea (up to 2%). Anorexia, colitis, dry mouth, dysgeusia, flatulence, gastrointestinal hemorrhage, stomach ulcers, tooth disorder, eructation, taste perversion, and thirst have been reported in less than 2% of patients. At least one case of reversible, functional intestinal obstruction and paralytic ileus has been reported. At least one case of Intestinal obstruction and epigastric pain has been reported. Gingival hyperplasia has been reported during postmarketing experience.[Ref]

A 72-year-old man developed gingival hyperplasia while receiving diltiazem. The hyperplasia recurred after surgical removal, and disappeared without recurrence after diltiazem was discontinued.

A 76-year-old man with CHF and an uncomplicated inguinal hernia developed epigastric pain, nausea, and vomiting associated with an unchanged ECG within 2 hours after starting diltiazem. Plain abdominal X-rays were suggestive of intestinal obstruction. The patient recovered within 24 hours after nasogastric suction, discontinuation of oral intake, and discontinuation of diltiazem. Rechallenge was not done.[Ref]

Dermatologic

In reported cases of acute generalized exanthematous pustular dermatitis, the rash developed 10 to 20 days after initiating diltiazem (the active ingredient contained in Diltia XT) therapy and resolved after discontinuation of the drug.[Ref]

Dermatologic side effects have included rash (up to 2%). Petechiae, photosensitivity, contact dermatitis, pruritus, sweating, skin hypertrophy (nevus), and urticaria have been reported in less than 2% of patients. Rarely, acute generalized exanthematous pustular dermatitis (at least 3 cases), subacute cutaneous, and lupoid lesions have been reported. At least 6 cases of photodistributed hyperpigmentation have been reported. Acute generalized exanthematous pustulosis, alopecia, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, photosensitivity (including lichenoid keratosis and hyperpigmentation at sun-exposed skin areas), and cases of generalized rash (characterized as leukocytoclastic vasculitis) have been reported during postmarketing experience.[Ref]

Hepatic

One patient developed both renal and hepatic failure while taking diltiazem (the active ingredient contained in Diltia XT) Although the drug was discontinued and renal and hepatic function were improving, the patient developed cardiogenic shock and died.

A 61-year-old man with hypertension and angina pectoris presented with fever and a generalized rash associated with hepatomegaly, a mild leukocytosis, thrombocytopenia, and elevated liver function tests. An infectious etiology was not found. After all of the patient's medications were continued except for diltiazem, his signs and symptoms resolved within six days. A macrophage inhibitory factor test and mast cell degranulation test done in the presence of diltiazem were positive.[Ref]

Hepatic side effects have included mild elevations of SGOT and SGPT in less than 2% of patients. Mild and transient increases in liver function tests have been reported. Rarely, granulomatous hepatitis and hepatorenal failure have been reported. Extremely rarely, acute hepatitis has been reported. A case of jaundice associated with elevated serum transaminases has been reported.[Ref]

Musculoskeletal

A 58-year-old man with hypertension, coronary artery disease, and hypercholesterolemia developed acute and generalized extremity weakness and chest pain while receiving diltiazem (the active ingredient contained in Diltia XT) lovastatin, nitrates, and enalapril. The patient's muscles were tender to palpation. An ECG was unchanged. With normal liver and thyroid function tests, lovastatin was discontinued, but the patient's creatine phosphokinase (CPK) levels remained elevated (all CPK-MM) and the patient's symptoms persisted. There was no evidence of a connective tissue disease, rhabdomyolysis, or renal failure. The patient refused muscle biopsy. Upon discontinuation of diltiazem, the signs and symptoms of myopathy rapidly resolved, even after lovastatin was readministered. All signs and symptoms recurred upon rechallenge with diltiazem.[Ref]

Musculoskeletal side effects have included back pain (up to 2.9%), myalgia (up to 2.3%), and gout (up to 2%). Muscle cramps, neck rigidity, arthralgia, arthrosis, bursitis, bone pain, and osteoarticular pain have been reported in less than 2% of patients. At least one case of acute myopathy has been reported.[Ref]

Metabolic

Metabolic side effects have included hyperglycemia, hyperuricemia, mild elevations of lactate dehydrogenase, mild elevations of alkaline phosphatase, and increased creatine phosphokinase in less than 2% of patients. Insulin resistance, diabetes-like symptoms, a case of attenuated hypoglycemia and symptoms of hypoglycemia, a case of polyuria, polydipsia, and elevated blood glucose, a case of frank hyperosmolar nonketotic hyperglycemic coma, a case of insulinoma, and at least one case of metabolic acidosis and hyperkalemia have been reported.

A 72-year-old man with coronary artery disease and esophagitis developed a urticarial rash and jaundice associated with elevated serum transaminases, metabolic acidosis, and hyperkalemia. The patient died of cardiogenic shock complicated by pulmonary edema.

A 46-year-old woman with insulinoma demonstrated suppressed serum insulin levels after diltiazem 44 mg intravenously was administered. The patient was subsequently treated with orally administered diltiazem, with a significant decrease in the frequency of hypoglycemic attacks.

Hypersensitivity

A 42-year-old man with a history of hypertension developed a generalized erythematous, purpuric rash associated with mucosal ulceration, fever, and elevated liver function tests within two days after starting diltiazem (the active ingredient contained in Diltia XT) A skin biopsy revealed histology consistent with Stevens-Johnson syndrome or severe erythema multiforme. The rash and liver function tests gradually resolved after discontinuation of diltiazem and institution of corticosteroid therapy. An extensive evaluation failed to reveal an infectious source.[Ref]

Hypersensitivity side effects have included allergic reaction (less than 2%). Erythematous rash, urticarial rash, and, rarely, cutaneous vasculitis and purpuric rash have been reported. Angioedema (including facial or periorbital edema) has been reported during postmarketing experience.[Ref]

Psychiatric

Psychiatric side effects have included nervousness (up to 2%). Abnormal dreams, depression, and personality change have been reported in less than 2% of patients. Reversible mania, acute psychosis, and at least one case of auditory and visual hallucinations, paranoia, and misinterpretations have been reported.[Ref]

A 72-year-old woman with hypertension and angina pectoris developed auditory and visual hallucinations, paranoia, and misinterpretations within two days after beginning diltiazem. In the absence of any other obvious cause, the diltiazem was stopped, and her psychosis resolved over the next three days. Nifedipine was successfully substituted.[Ref]

Hematologic

A 23-year-old man with a carotid aneurysm and delirium developed an increased bleeding time (15 minutes) after starting aminocaproic acid, phenobarbital, and diltiazem (the active ingredient contained in Diltia XT) His bleeding time resolved to his pretreatment time of 6 minutes after diltiazem alone was discontinued.

A 61-year-old man with hypertension and angina pectoris presented with fever and a generalized rash associated with hepatomegaly, a mild leukocytosis, thrombocytopenia, and elevated liver function tests. An infectious etiology was not found. After all of the patient's medications were continued except for diltiazem, his signs and symptoms resolved within six days. A macrophage inhibitory factor test and mast cell degranulation test done in the presence of diltiazem were positive.[Ref]

Hematologic side effects have included platelet dysfunction and at least one case of mild leukocytosis. Hemolytic anemia, increased bleeding time, leukopenia, lymphadenopathy, purpura, and thrombocytopenia have been reported during postmarketing experience.[Ref]

Ocular

Ocular side effects have included conjunctivitis (up to 2%). Amblyopia, eye irritation, eye hemorrhage, and ophthalmitis have been reported in less than 2% of patients. Retinopathy has been reported during postmarketing experience.

Genitourinary

Genitourinary side effects have included impotence (up to 2%). Albuminuria, crystalluria, cystitis, kidney calculus, dysmenorrheal, nocturia, polyuria, sexual difficulties, vaginitis, prostate disease, gynecomastia, and urinary tract infection have been reported in less than 2% of patients.

Renal

A 53-year-old man, with hypertension and ischemic heart disease, developed a rash and acute renal failure associated with elevated liver function tests following a single dose of diltiazem (the active ingredient contained in Diltia XT)

Several case reports have been published describing renal failure, which appear to be related to diltiazem. A 72-year-old man with coronary artery disease and esophagitis developed a urticarial rash and jaundice associated with elevated serum transaminases, metabolic acidosis, and hyperkalemia. The patient died of cardiogenic shock complicated by pulmonary edema.[Ref]

Renal side effects have included kidney failure and pyelonephritis in less than 1% of patients. Acute renal failure has been reported.[Ref]

Local

Local side effects have included injection site reactions (e.g., itching, burning) in 3.9% of patients.

References

1. Woehler TR, Eff J, Graney W, et al "Multicenter evaluation of the efficacy and safety of sustained-release diltiazem hydrochloride for the treatment of hypertension." Clin Ther 14 (1992): 148-57

2. Lind L, Lithell H, Johansson CG, Morlin C, Ljunghall S "Electrocardiographic changes during antihypertensive treatment with diltiazem in relation to the achieved serum levels of the drug." Scand J Clin Lab Invest 54 (1994): 337-40

3. Kinney EL, Moskowitz RM, Zelis R "The pharmacokinetics and pharmacology of oral diltiazem in normal volunteers." J Clin Pharmacol 21 (1981): 337-42

4. Cutler NR, Eff J, Fromell G, Brass EP, Archer S, Chrysant SG, Fiddes R "Dose-ranging study of a new, once-daily diltiazem formulation for patients with stable angina." J Clin Pharmacol 35 (1995): 189-95

5. Hutt V, Janik F, Kappler J, Pabst G, Ravelli V, Maccari M, Jaeger H "Evaluation of pharmacokinetics, bioavailability and dose linearity of diltiazem in healthy volunteers." Arzneimittelforschung 43 (1993): 737-43

6. Friedland S, Kaplan S, Lahav M, Shapiro A "Proptosis and periorbital edema due to diltiazem treatment." Arch Ophthalmol 111 (1993): 1027-8

7. "Product Information. Cardizem (diltiazem)." Hoechst Marion-Roussel Inc, Kansas City, MO.

8. Patel R, Lipper B, Schwartzbard A, Nelson C, Oconnor MA, Frishman W "Toxic effects of diltiazem in a patient with chronic renal failure." J Clin Pharmacol 34 (1994): 273-4

9. Gobel EJAM, Hautvast RWM, Vangilst WH, Spanjaard JN, Hillege HL, Dejongste MJL, Molhoek GP, Lie KI "Randomised, double-blind trial of intravenous diltiazem versus glyceryl trinitrate for unstable angina pectoris." Lancet 346 (1995): 1653-7

10. Reams GP, Lau A, Messina C, et al "Efficacy, electrocardiographic and renal effects of intravenous diltiazem for essential hypertension." Am J Cardiol 60 (1987): i78-84

11. Kubota K, Pearce GL, Inman WHW "Vasodilation-related adverse events in diltiazem and dihydropyridine calcium antagonists studied by prescription-event monitoring." Eur J Clin Pharmacol 48 (1995): 1-7

12. Weir MR "Diltiazem: ten years of clinical experience in the treatment of hypertension." J Clin Pharmacol 35 (1995): 220-32

13. Goldenberg IF, Lewis WR, Dias VC, Heywood JT, Pedersen WR "Intravenous diltiazem for the treatment of patients with atrial fibrillation or flutter and moderate to severe congestive heart failure." Am J Cardiol 74 (1994): 884-9

14. Andrivet P, Beaslay V, Kiger JP, Gnoc CV "Complete sinus arrest during diltiazem therapy - clinical correlates and efficacy of intravenous calcium." Eur Heart J 15 (1994): 350-4

15. Malcolm N, Callegari P, Goldberg J, et al "Massive diltiazem overdosage: clinical and pharmacokinetic observations." Drug Intell Clin Pharm 20 (1986): 888

16. Nagle RE, Low-Beer T, Horton R "Diltiazem and heart block." Lancet Apr (1989): 907

17. Nicaise J, Neveux E, Blondin P, Aquino JP, Barrel A, Fanon JL, Coupez JM, Hargrave DC "Antihypertensive efficacy and safe use of once-daily sustained-release diltiazem in the elderly: a comparison with captopril." J Int Med Res 23 (1995): 244-53

18. Boden WE, Moss AJ, Herbert PN, Savitelli A, Oakes D, Eberly S "Effect of long-term-diltiazem administration on serum lipids in post-myocardial infarction survivors." Am J Cardiol 73 (1994): 513-4

19. Imamura T, Koiwaya Y, Nakamura M "Sinoatrial block induced by oral diltiazem." Clin Cardiol 9 (1986): 33-4

20. Nadeau C, Hilton D, Savard D, Morin Y, Baird M, Alexander M, Langer G, Roth D, Boulet AP, Lariviere L "Three-month efficacy and safety of once-daily diltiazem in chronic stable angina pectoris." Am J Cardiol 75 (1995): 555-8

21. Ellenbogen KA, Roark SF, Smith MS, et al "Effects of sustained intravenous diltiazem infusion in healthy persons." Am J Cardiol 58 (1986): 1055-60

22. Graney WF "Clinical experience with a once-daily, extended-release formulation of diltiazem in the treatment of hypertension." Am J Med 93 (1992): s56-64

23. Ellenbogen KA, Dias VC, Cardello FP, Strauss WE, Simonton CA, Pollak SJ, Wood MA, Stambler BS "Safety and efficacy of intravenous diltiazem in atrial fibrillation or atrial flutter." Am J Cardiol 75 (1995): 45-9

24. Palat GK, Hooker EA, Movahed A "Secondary mania associated with diltiazem." Clin Cardiol 7 (1984): 611-2

25. Jacobs MB "Diltiazem and akathisia." Ann Intern Med 99 (1983): 794-5

26. Jeret JS "Diltiazem-induced myoclonus." Neurology 59 (2002): 962-4

27. Graham DF, Stewartwynne EG "Diltiazem - induced acute parkinsonism." Aust N Z J Med 24 (1994): 70

28. Jacobs MB "Diltiazem and akathisia." Ann Intern Med 99 (1983): 794-5

29. Berman JL "Dysomia, dysgeusia, and diltiazem." Ann Intern Med 102 (1985): 558

30. Dick RS, Barold SS "Diltiazem-induced parkinsonism." Am J Med 87 (1989): 95-6

31. Brink DD "Diltiazem and hyperactivity." Ann Intern Med 100 (1984): 459-60

32. Palat GK, Hooker EA, Movahed A "Secondary mania associated with diltiazem." Clin Cardiol 8 (1985): 251-2

33. Palat GK, Hooker EA, Movahed A "Secondary mania associated with diltiazem." Clin Cardiol 9 (1986): 39

34. Raptis L, Pappas G, Katsanou A, Koutsouka F, Petrakis D, Akritidis N "Diltiazem-induced eosinophilic pleural effusion." Pharmacotherapy 27 (2007): 600-2

35. King GN, Fullinfaw R, Higgins TJ, Walker RG, Francis DM, Wiesenfeld D "Gingival hyperplasia in renal allograft recipients receiving cyclosporin-A and calcium antagonists." J Clin Periodontol 20 (1993): 286-93

36. Steele RM, Schuna AA, Schreiber RT "Calcium antagonist-induced gingival hyperplasia." Ann Intern Med 120 (1994): 663-4

37. Tam IM, Wandres DL "Calcium-channel blockers and gingival hyperplasia." Ann Pharmacother 26 (1992): 213-4

38. Mantzoros CS, Prabhu AS, Sowers JR "Paralytic ileus as a result of diltiazem treatment." J Intern Med 235 (1994): 613-4

39. Bullon P, Machuca G, Martinezsahuquillo A, Rios JV, Velasco E, Rojas J, Lacalle JR "Evaluation of gingival and periodontal conditions following causal periodontal treatment in patients treated with nifedipine and diltiazem." J Clin Periodontol 23 (1996): 649-57

40. Bullon P, Machuca G, Msahuquillo A, Rojas J, Lacalle JR, Rios JV, Velasco E "Clinical assessment of gingival size among patients treated with diltiazem." Oral Surg Oral Med Oral Pathol 79 (1995): 300-4

41. Trimarco B, Radzik D, Vanmieghem W, Neveux E, Wajman A, Attali P, Ponsonnaille J "Efficacy and safety of the 200-300 mg sustained release formulation of diltiazem administered once daily in patients with stable angina." Eur J Clin Pharmacol 47 (1995): 493-6

42. Giustiniani S, Cuna F, Marieni M "Hyperplastic gingivitis during diltiazem therapy." Int J Cardiol 15 (1987): 247-9

43. Bowman JM, Levy BA, Grubb RV "Gingival overgrowth induced by diltiazem." Oral Surg Oral Med Oral Pathol 65 (1988): 183-5

44. Lavrijsen APM, Van Dijke C, Vermeer BJ "Diltiazem-associated exfoliative dermatitis in a patient with psoriasis." Acta Derm Venereol 66 (1986): 536-8

45. Seggev JS, Lagstein Z "Photosensitivity skin reactions to calcium channel blockers." J Allergy Clin Immunol 97 (1996): 852-5

46. Jones SK, Reynolds NJ, Crossley J, Kennedy CT "Cutaneous reaction to diltiazem resulting in an exacerbation of angina." Clin Exp Dermatol 14 (1989): 457-8

47. Wirebaugh SR, Geraets DR "Reports of erythematous macular skin eruptions associated with diltiazem therapy." DICP 24 (1990): 1046-9

48. Chawla A, Goyal S "Diltiazem-induced hyperpigmentation in an African American woman." J Am Acad Dermatol 46 (2002): 468-9

49. Scherschun L, Lee MW, Lim HW "Diltiazem-associated photodistributed hyperpigmentation - A review of 4 cases." Arch Dermatol 137 (2001): 179-82

50. Crowson AN, Magro CM "Diltiazem and subacute cutaneous lupus erythematosis-like lesions." N Engl J Med 333 (1995): 1429

51. Sheehan-Dare RA, Goodfield MJD "Widespread cutaneous vasculitis associated with diltiazem." Postgrad Med J 64 (1988): 467-8

52. Odeh M "Exfoliative dermatitis associated with diltiazem." J Toxicol Clin Toxicol 35 (1997): 101-4

53. Sheehan-Dare RA, Goodfield MJ "Severe cutaneous vasculitis induced by diltiazem." Br J Dermatol 119 (1988): 134

54. Dominguez EA, Hamill RJ "Drug-induced fever due to diltiazem." Arch Intern Med 151 (1991): 1869-70

55. Lambert DG, Dalac S, Beer F, et al "Acute generalized exanthematous pustular dermatitis induced by diltiazem." Br J Dermatol 118 (1988): 308-9

56. Wakelin SH, James MP "Diltiazem-induced acute generalised exanthematous pustulosis." Clin Exp Dermatol 20 (1995): 341-4

57. Stern R, Khalsa JH "Cutaneous adverse reactions associated with calcium channel blockers." Arch Intern Med 149 (1989): 829-32

58. Avila JR "Elevation of hepatic enzymes after cutaneous reaction caused by diltiazem." Ann Pharmacother 29 (1995): 317-8

59. Berendzen SM, Carey JD, Smith EB "Diltiazem-associated photodistributed hyperpigmentation in an elderly Hispanic female." Int J Dermatol 45 (2006): 1450-2

60. Sidoroff A, Dunant A, Viboud C, et al. "Risk factors for acute generalized exanthematous pustulosis (AGEP)-results of a multinational case-control study (EuroSCAR)." Br J Dermatol 157 (2007): 989-96

61. Carmichael AJ, Paul CJ "Vasculitic leg ulcers associated with diltiazem." Br Med J 297 (1988): 562

62. Taylor JW, Cleary JD, Atkinson RC "Stevens-Johnson syndrome associated with diltiazem." Clin Pharm 9 (1990): 948-50

63. Scolnick B, Brinberg D "Diltiazem and generalized lymphadenopathy." Ann Intern Med 102 (1985): 558

64. Wakeel RA, Gavin MP, Keefe M "Severe toxic erythema caused by diltiazem." Br Med J 296 (1988): 1071

65. Shallcross H, Padley SP, Glynn MJ, Gibbs DD "Fatal renal and hepatic toxicity after treatment with diltiazem." Br Med J 295 (1987): 1256-7

66. Toft E, Vyberg M, Therkelsen K "Diltiazem-induced granulomatous hepatitis." Histopathology 18 (1991): 474-5

67. ter Wee PM, Rosman JB, van der Geest S "Acute renal failure due to diltiazem." Lancet 2 (1984): 1337-8

68. Traverse JH, Swenson LJ, Mcbride JW "Acute hepatic injury after treatment with diltiazem." Am Heart J 127 (1994): 1636-9

69. Saracheck NS, London RL, Matulewicz TJ, et al "Diltiazem and granulomatous hepatitis." Gastroenterology 88 (1985): 1260-2

70. Ahmad S "Diltiazem myopathy." Am Heart J 126 (1993): 1494-5

71. Romano A, Pietrantonio F, Garcovich A, et al "Delayed hypersensitivity to diltiazem in two patients." Ann Allergy 69 (1992): 31-2

72. Sousa-Basto A, Azenha A, Duarte ML, Pardal-Oliveira F "Generalized cutaneous reaction to diltiazem." Contact Dermatitis 29 (1993): 44-5

73. Sanders CJ, Neumann HA "Erythema multiforme, Stevens-Johnson syndrome, and diltiazem." Lancet 341 (1993): 967

74. Bushe CJ "Organic psychosis caused by diltiazem." J R Soc Med 81 (1988): 296-7

75. Hubbard JR, Levenson JL, Patrick GA "Psychiatric side effects associated with the ten most commonly dispensed prescription drugs: a review." J Fam Pract 33 (1991): 177-86

76. Biriell C, McEwen J, Sanz E "Depression associated with diltiazem." Br Med J 299 (1989): 796

77. Ring ME, Corrigan JJ, Fenster PE "Effects of oral diltiazem on platelet function: alone and in combination with "low dose" aspirin." Thromb Res 44 (1986): 391-400

78. Lahav M, Arav R "Diltiazem and thrombocytopenia." Ann Intern Med 110 (1989): 327

79. Saunders FW, Shedden P "Diltiazem: possible hematologic complications." Surg Neurol 25 (1986): 82-4

80. Ring ME, Corrigan JJ Jr, Fenster PE "Antiplatelet effects of oral diltiazem, propranolol, and their combination." Br J Clin Pharmacol 24 (1987): 615-20

81. Abadin JA, Duran JA, deLeon JAP "Probable diltiazem-induced acute interstitial nephritis." Ann Pharmacother 32 (1998): 656-8

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