Diclofenac ophthalmic Side Effects

Not all side effects for diclofenac ophthalmic may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to diclofenac ophthalmic: ophthalmic solution

Along with its needed effects, diclofenac ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking diclofenac ophthalmic:

More common
  • Eye redness, irritation, or pain
  • tearing of the eyes
Less common
  • Blindness
  • blurred vision
  • burning, dry, or itching eyes
  • clear or yellow fluid from the eye
  • decreased vision or any change in vision
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • sensitivity to light
  • sticky or matted eyelashes
  • throbbing pain
Incidence not known
  • Feeling of something in the eye

Some side effects of diclofenac ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Burning and stinging of the eye
Less common
  • Abdominal or stomach pain
  • chills
  • cold flu-like symptoms
  • cough or hoarseness
  • dizziness
  • fever
  • headache
  • lack or loss of strength
  • nausea
  • pain
  • runny nose
  • sleeplessness
  • sneezing
  • stuffy nose
  • swelling or puffiness of the face
  • trouble with sleeping
  • unable to sleep
  • vomiting

For Healthcare Professionals

Applies to diclofenac ophthalmic: ophthalmic solution

Ocular

Ocular side effects including transient burning and stinging upon instillation has been reported in approximately 15% of patients.
In cataract surgery studies, keratitis was reported in up to 28% of patients, although in many of these cases keratitis was initially noted prior to the initiation of treatment. Elevated intraocular pressure following cataract surgery was reported in approximately 15% of patients undergoing cataract surgery. Lacrimation complaints were reported in approximately 30% of case studies undergoing incisional refractive surgery. The following adverse reactions were reported in approximately 10% or less of patients: abnormal vision, acute elevated IOP, blurred vision, conjunctivitis, corneal deposits, corneal edema, corneal opacity, corneal lesions, discharge, eyelid swelling, eye pain, injection (redness), iritis, irritation, itching, lacrimation disorder, and ocular allergy.

Postmarketing reports have included corneal erosion, corneal infiltrates, corneal perforation, corneal thinning, corneal ulceration, epithelial breakdown, and superficial punctate keratitis.

The use of diclofenac eyedrops has been associated with the development of persistent epithelial defects of the cornea (ranging from punctate superficial keratopathy to corneal melt) in patients undergoing ocular surgery. Diclofenac eyedrops should be used with great care in patients with disorders of the corneal epithelium. Blurred vision, dry eyes, scotoma, conjunctivitis, corneal deposits, corneal edema, corneal opacity, corneal lesions, discharge, eyelid swelling, eye pain, injection (redness), iritis, irritation, itching, lacrimation disorder, ocular allergy, transient stinging or burning and amblyopia have been reported.

Gastrointestinal

Gastrointestinal side effects include nausea or vomiting in 1% to 3% of patients. Abdominal pain has also been reported.

Hypersensitivity

Local hypersensitivity reactions have been reported in 1% of patients.

Nervous system

Rarely, headache and insomnia have been reported. Asthenia and dizziness have also been reported.

Hepatic

Hepatic side effects have included reports of drug-induced hepatotoxicity occurring in the first month, and in some cases, the first 2 months of therapy, but have occurred at any time during treatment with diclofenac. Postmarketing surveillance has reported cases of severe hepatic reactions, including liver necrosis, jaundice, fulminant hepatitis with and without jaundice, and liver failure. Some of these reported cases resulted in fatalities or liver transplantation.

General

General side effects have included chills, facial edema, fever, pain, and viral infection.

Respiratory

Respiratory side effects have included rhinitis.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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