Dextromethorphan / phenylephrine / pyrilamine Side Effects
For the Consumer
Applies to dextromethorphan / phenylephrine / pyrilamine: chewable tablets
Other dosage forms:
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur while taking dextromethorphan / phenylephrine / pyrilamine:
Constipation; diarrhea; dizziness; drowsiness; excitability; headache; loss of appetite; nausea; nervousness or anxiety; upset stomach; vomiting; weakness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor; trouble sleeping; vision changes.
For Healthcare Professionals
Applies to dextromethorphan / phenylephrine / pyrilamine: oral liquid, oral suspension, oral suspension extended release, oral syrup, oral tablet chewable, oral tablet chewable extended release
Cardiovascular side effects including arrhythmias, hypertension, hypotension, and palpitations have been reported.[Ref]
Nervous system side effects including coordination disturbances, drowsiness, dysphoria, euphoria, headache, insomnia, irritability, nervousness, sedation, and seizures have been reported.[Ref]
Dermatologic side effects including photosensitivity, pruritus, rash, and urticaria have been reported.[Ref]
Gastrointestinal side effects including constipation, diarrhea, epigastric discomfort, nausea, vomiting, and xerostomia have been reported.[Ref]
Genitourinary side effects including difficult urination and urinary frequency have been reported.[Ref]
Hematologic side effects including agranulocytosis, hemolytic anemia, and thrombocytopenia have been reported.[Ref]
Neuromuscular side effects including tremor and weakness have been reported.[Ref]
Ocular side effects including visual disturbances have been reported.[Ref]
Respiratory side effects including shortness of breath and wheezing have been reported.[Ref]
1. "Product Information. Codal-DM Syrup (dextromethorphan / phenylephrine / pyrilamine)." Cypress Pharmaceutical Inc, Madison, MS.
2. "Product Information. Viravan-DM (dextromethorphan / phenylephrine / pyrilamine)." PediaMed Pharmaceuticals Inc, Exton, PA.
Not all side effects for dextromethorphan / phenylephrine / pyrilamine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
More about dextromethorphan/phenylephrine/pyrilamine
- Dextromethorphan/phenylephrine/pyrilamine chewable tablets
- Dextromethorphan/phenylephrine/pyrilamine suspension
- Phenylephrine/pyrilamine/dextromethorphan drops
- Phenylephrine/pyrilamine/dextromethorphan syrup
- Dextromethorphan, phenylephrine, and pyrilamine
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