DexPak Side Effects

Please note - some side effects for DexPak may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of DexPak - for the Consumer

DexPak Tablets (dose pack)

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using DexPak Tablets (dose pack):

Difficulty sleeping; feeling of a whirling motion; increased appetite; increased sweating; indigestion; mood changes; nervousness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); appetite loss; black, tarry stools; changes in menstrual periods; convulsions; depression; diarrhea; dizziness; exaggerated sense of well-being; fever; general body discomfort; headache; increased pressure in the eye; joint or muscle pain; mood swings; muscle weakness; personality changes; prolonged sore throat, cold, or fever; puffing of the face; severe nausea or vomiting; swelling of feet or legs; unusual weight gain; vomiting material that looks like coffee grounds; weakness; weight loss.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Side Effects by Body System - for Healthcare Professionals

Applies to: compounding powder; inhalation aerosol with adapter; injectable solution; injectable suspension; intravenous solution; oral concentrate; oral liquid; oral tablet

Cardiovascular

Cardiovascular side effects have included bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, fat embolism, hypertension, myocardial rupture following recent myocardial infarction, edema, pulmonary edema, syncope, tachycardia, thromboembolism, thrombophlebitis and vasculitis.

Musculoskeletal

Musculoskeletal side effects have included muscle weakness, steroid myopathy, loss of muscle mass, osteoporosis, vertebral compression fractures, aseptic necrosis of femoral and humoral heads, pathologic fracture of long bones, and tendon rupture.

Gastrointestinal

Gastrointestinal side effects have included peptic ulcer with potential perforation and hemorrhage, perforation of small and large bowel, pancreatitis, abdominal distention, nausea, increased appetite, and ulcerative esophagitis.

Endocrine

Endocrine side effects have included development of cushingoid state, suppression of growth in children, and secondary adrenocortical and pituitary unresponsiveness.

Nervous system

Nervous system side effects have included convulsions, increased intracranial pressure with papilledema, vertigo, myalgia, arthralgia, malaise, headache, hiccups, and psychic disturbances.

Metabolic

Metabolic side effects have included negative nitrogen balance due to protein catabolism, decreased carbohydrate and glucose tolerance, weight gain, hirsutism, hypokalemic alkalosis, and increased requirements for insulin or oral hypoglycemic agents in diabetics.

Ocular

Ocular side effects have included posterior subcapsular cataracts, increased intraocular pressure, glaucoma, and exophthalmos.

Dermatologic

Dermatologic side effects have included impaired wound healing, thin fragile skin, petechiae and ecchymoses, dry scaly skin, erythema, acne, thinning scalp hair, urticaria, increased sweating, rash, striae, allergic dermatitis, urticaria, angioneurotic edema, and suppression of skin test reactions.

Psychiatric

Psychiatric side effects have included euphoria, insomnia, mood swings, personality changes, severe depression, and psychotic manifestations.

Hematologic

Hematologic side effects have included rare reports of thromboembolism.

Genitourinary

Genitourinary effects have included increase/decrease in motility and number of spermatozoa in men and menstrual irregularities in women.

Hepatic

Hepatic side effects have included reports of reversible hepatomegaly. Three case reports of children treated with high dose dexamethasone describe the earliest diagnosis of hepatomegaly as early as 8 days from the start of therapy.

Hypersensitivity

Hypersensitivity side effects have included anaphylactoid reactions, anaphylaxis and angioedema.

Renal

Renal side effects have included fluid retention, sodium retention, and potassium loss,

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