Dexedrine Side Effects

Generic Name: dextroamphetamine

Note: This page contains information about the side effects of dextroamphetamine. Some of the dosage forms included on this document may not apply to the brand name Dexedrine.

Not all side effects for Dexedrine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to dextroamphetamine: oral capsule extended release, oral solution, oral tablet

Along with its needed effects, dextroamphetamine (the active ingredient contained in Dexedrine) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dextroamphetamine:

Rare
  • Agitation
  • delusions
  • seeing, hearing, or feeling things that are not there
Incidence not known
  • Blurred vision
  • chest discomfort or pain
  • difficulty breathing
  • dizziness
  • faintness
  • false or unusual sense of well-being
  • fast, pounding, or irregular heartbeat or pulse
  • headache
  • nervousness
  • pounding in the ears
  • restlessness
  • shakiness in the legs, arms, hands, or feet
  • swelling of the feet or lower legs
  • trembling or shaking of the hands or feet
  • trouble sleeping
  • troubled breathing
  • twitching, twisting, or uncontrolled repetitive movements of tongue, lips, face, arms, or legs
  • unable to sleep
  • uncontrolled vocal outbursts and/or tics (uncontrolled repeated body movements)
  • unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking dextroamphetamine:

Symptoms of overdose
  • Change in consciousness
  • dark-colored urine
  • diarrhea
  • discouragement
  • feeling sad or empty
  • fever
  • irritability
  • lack of appetite
  • loss of consciousness
  • loss of interest or pleasure
  • mood or mental changes
  • muscle cramps or spasms
  • muscle pain or stiffness
  • nausea
  • panic state
  • physical attempt to injure
  • rapid breathing
  • seizures
  • stomach cramps
  • sweating
  • trouble concentrating
  • violent actions
  • vomiting

Some side effects of dextroamphetamine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known
  • Bad, unusual, or unpleasant (after) taste
  • change in taste
  • constipation
  • decreased interest in sexual intercourse
  • dry mouth
  • hives or welts
  • inability to have or keep an erection
  • indigestion
  • itching
  • loss in sexual ability, desire, drive, or performance
  • passing of gas
  • redness of the skin
  • skin rash
  • weight loss

For Healthcare Professionals

Applies to dextroamphetamine: oral capsule extended release, oral solution, oral tablet

Cardiovascular

Cardiovascular side effects have included palpitations, tachycardia, and elevated blood pressure. Cardiomyopathy, myocardial infarction, and sudden death have been reported rarely.

Nervous system

Nervous system side effects have included overstimulation, restlessness, dizziness, insomnia, euphoria, dyskinesia, dysphoria, tremor, headache, exacerbation of motor and phonic tics, and Tourette's Syndrome.

It is unclear whether CNS stimulant drugs (i.e., dextroamphetamine, methylphenidate, mixed- salts amphetamine) have a role in either the development or worsening of tic disorders such as Tourette's syndrome. According to several case reports, use of CNS stimulant medications may have precipitated or exacerbated tic disorders in some patients with ADHD. Based on these cases, in Tourette's-susceptible patients, CNS stimulants may exacerbate motor and phonic tics that do not subside following discontinuation of the offending agent. In several controlled studies involving patients with ADHD and tic disorders, in the majority of patients, tics did not increase following use of CNS stimulants. In addition, controlled studies have not found that methylphenidate worsens motor tics in Tourette's syndrome nor has it increased tics in patients without Tourette's. However, it should be noted that tics were reported in 7% of patients using the methylphenidate patch compared to 1% to those taking it orally. Additional studies are required in order to clarify this association.

Gastrointestinal

Gastrointestinal side effects have included dry mouth, unpleasant taste, diarrhea, constipation, (undesired) anorexia and weight loss, and other disturbances.

Dermatologic

Dermatologic side effects have included urticaria.

Endocrine

Endocrine side effects have included impotence, changes in libido and frequent or prolonged erections.

Other

Amphetamines may interfere with urinary steroid determination.

Other side effects have included a significant elevation (highest in the evening) of the plasma corticosteroid levels.

Psychiatric

Psychotic episodes at recommended doses have been reported rarely.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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