Dexedrine Side Effects

Generic Name: dextroamphetamine

Please note - some side effects for Dexedrine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Dexedrine - for the Consumer

Dexedrine

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Dexedrine:

Constipation; diarrhea; dizziness; dry mouth; headache; loss of appetite; mild weight loss; nausea; restlessness; trouble sleeping; unpleasant taste; upset stomach.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; change in sexual ability or desire; chest pain or tightness; fainting; fast or irregular heartbeat; hallucinations; mental or mood changes (eg, aggression, hostility, new or worsening behavior or thought problems); numbness of an arm or leg; seizures; severe dizziness or headache; shortness of breath; significant weight loss; sudden vision changes; symptoms of stroke (eg, confusion, one-sided weakness, slurred speech); tremor; uncontrolled speech or muscle movements (eg, tics); unusual weakness or tiredness; vomiting.

Dexedrine Spansule Sustained-Release Capsules

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Dexedrine Spansule Sustained-Release Capsules:

Constipation; diarrhea; dizziness; dry mouth; headache; loss of appetite; mild weight loss; nausea; restlessness; trouble sleeping; unpleasant taste; upset stomach.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; change in sexual ability or desire; chest pain or tightness; fainting; fast or irregular heartbeat; hallucinations; mental or mood changes (eg, aggression, hostility, new or worsening behavior or thought problems); numbness of an arm or leg; seizures; severe dizziness or headache; shortness of breath; significant weight loss; sudden vision changes; symptoms of stroke (eg, confusion, one-sided weakness, slurred speech); tremor; uncontrolled speech or muscle movements (eg, tics); unusual weakness or tiredness; vomiting.

Dexedrine Side Effects - for the Professional

Dexedrine

Cardiovascular

Palpitations, tachycardia, elevation of blood pressure. There have been isolated reports of cardiomyopathy associated with chronic amphetamine use.

Central Nervous System

Psychotic episodes at recommended doses (rare), overstimulation, restlessness, dizziness, insomnia, euphoria, dyskinesia, dysphoria, tremor, headache, exacerbation of motor and phonic tics, and Tourette’s syndrome.

Gastrointestinal

Dryness of the mouth, unpleasant taste, diarrhea, constipation, other gastrointestinal disturbances. Anorexia and weight loss may occur as undesirable effects.

Allergic

Urticaria.

Endocrine

Impotence, changes in libido.

Side Effects by Body System

Cardiovascular

Cardiovascular side effects have included palpitations, tachycardia, and elevated blood pressure. Cardiomyopathy, myocardial infarction, and sudden death have been reported rarely.

Nervous system

Nervous system side effects have included overstimulation, restlessness, dizziness, insomnia, euphoria, dyskinesia, dysphoria, tremor, headache, exacerbation of motor and phonic tics, and Tourette's syndrome. Psychotic episodes at recommended doses have been reported rarely.

It is unclear whether CNS stimulant drugs (i.e., dextroamphetamine, methylphenidate, mixed- salts amphetamine) have a role in either the development or worsening of tic disorders such as Tourette's syndrome. According to several case reports, use of CNS stimulant medications may have precipitated or exacerbated tic disorders in some patients with ADHD. Based on these cases, in Tourette's-susceptible patients, CNS stimulants may exacerbate motor and phonic tics that do not subside following discontinuation of the offending agent. In several controlled studies involving patients with ADHD and tic disorders, in the majority of patients, tics did not increase following use of CNS stimulants. In addition, controlled studies have not found that methylphenidate worsens motor tics in Tourette's syndrome nor has it increased tics in patients without Tourette's. However, it should be noted that tics were reported in 7% of patients using the methylphenidate patch compared to 1% to those taking it orally. Additional studies are required in order to clarify this association.

Gastrointestinal

Gastrointestinal side effects have included dry mouth, unpleasant taste, diarrhea, constipation, (undesired) anorexia and weight loss, and other disturbances.

Dermatologic

Dermatologic side effects have included urticaria.

Endocrine

Endocrine side effects have included impotence and changes in libido.

Other

Amphetamines may interfere with urinary steroid determination.

Other side effects have included a significant elevation (highest in the evening) of the plasma corticosteroid levels.

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