Dexamethasone Sodium Phosphate Side Effects

Generic Name: dexamethasone

Please note - some side effects for Dexamethasone Sodium Phosphate may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Dexamethasone Sodium Phosphate Side Effects - for the Professional

Dexamethasone Sodium Phosphate

Fluid and electrolyte disturbances

 

Sodium retention

 

Fluid retention

 

Congestive heart failure in susceptible patients

 

Potassium loss

 

Hypokalemic alkalosis

 

Hypertension

Musculoskeletal

 

Muscle weakness

 

Steroid myopathy

 

Loss of muscle mass

 

Osteoporosis

 

Vertebral compression fractures

 

Aseptic necrosis of femoral and humeral heads

 

Pathologic fracture of long bones

 

Tendon rupture

Gastrointestinal

 

Peptic ulcer with possible subsequent perforation and hemorrhage

 

Perforation of the small and large bowel, particularly in patients with inflammatory bowel disease

 

Pancreatitis

 

Abdominal distention

 

Ulcerative esophagitis

Dermatologic

 

Impaired wound healing

 

Thin fragile skin

 

Petechiae and ecchymoses

 

Erythema

 

Increased sweating

 

May suppress reactions to skin tests

 

Burning or tingling, especially in the perineal area (after I.V. injection)

 

Other cutaneous reactions, such as allergic dermatitis, urticaria, angioneurotic edema

Neurologic

 

Convulsions

 

Increased intracranial pressure with papilledema (pseudotumor cerebri) usually after treatment

 

Vertigo

 

Headache

 

Psychic disturbances

Endocrine

 

Menstrual irregularities

 

Development of cushingoid state

 

Suppression of growth in children

 

Secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery, or illness

 

Decreased carbohydrate tolerance

 

Manifestations of latent diabetes mellitus

 

Increased requirements for insulin or oral hypoglycemic agents in diabetics

 

Hirsutism

Ophthalmic

 

Posterior subcapsular cataracts

 

Increased intraocular pressure

 

Glaucoma

 

Exophthalmos

Metabolic

 

Negative nitrogen balance due to protein catabolism

Cardiovascular

 

Myocardial rupture following recent myocardial infarction.

Other

 

Anaphylactoid or hypersensitivity reactions

 

Thromboembolism

 

Weight gain

 

Increased appetite

 

Nausea

 

Malaise

 

Hiccups

 

The following additional adverse reactions are related to parenteral corticosteroid therapy:

 

Rare instances of blindness associated with intralesional therapy around the face and head

 

Hyperpigmentation or hypopigmentation

 

Subcutaneous and cutaneous atrophy

 

Sterile abscess

 

Postinjection flare (following intra-articular use)

 

Charcot-like arthropathy

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