Desyrel Dividose Side Effects

Generic name: trazodone

Medically reviewed by Drugs.com. Last updated on Oct 20, 2022.

Note: This document contains side effect information about trazodone. Some dosage forms listed on this page may not apply to the brand name Desyrel Dividose.

Applies to trazodone: oral tablet, oral tablet extended release.

Warning

Oral route (Tablet, Extended Release; Tablet)

Antidepressants increased the risk compared to placebo of suicidal thinking and behavior in children, adolescents, and young adults with major depressive disorder (MDD) and other psychiatric disorders in short-term studies. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared with placebo in adults beyond age 24, and there was a reduction in risk with antidepressants compared with placebo in adults aged 65 or older. The use of trazodone hydrochloride or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Closely monitor patients of all ages for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Not approved for pediatric use.

Serious side effects of Desyrel Dividose

Along with its needed effects, trazodone (the active ingredient contained in Desyrel Dividose) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking trazodone:

More common

Blurred vision
confusion
dizziness
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
lightheadedness
sweating
unusual tiredness or weakness

Less common

Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
confusion about identity, place, and time
decreased concentration
fainting
general feeling of discomfort or illness
headache
lack of coordination
muscle tremors
nervousness
pounding in the ears
shortness of breath
slow or fast heartbeat
swelling

Rare

Skin rash
unusual excitement

Other side effects of Desyrel Dividose

Some side effects of trazodone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Dry mouth (usually mild)
muscle or bone pain
trouble sleeping
trouble with remembering
unpleasant taste

Less common

Constipation
continuing ringing or buzzing or other unexplained noise in the ears
diarrhea
hearing loss
muscle aches or pains
weight loss

For Healthcare Professionals

Applies to trazodone: compounding powder, oral tablet, oral tablet extended release.

General

The most commonly reported side effects included drowsiness, dry mouth, dizziness, and lightheadedness.^[Ref]

Nervous system

Very common (10% or more): Drowsiness (up to 41%), dizziness (up to 28%), lightheadedness (up to 28%), headache (up to 20%)

Common (1% to 10%): Decreased concentration, head full-heavy, incoordination, syncope, tremor

Frequency not reported: Akathisia, altered taste, convulsion, decreased alertness, dystonia, expressive aphasia, impaired memory, impaired speech, memory disturbance, motor impairment, neuroleptic malignant syndrome, numbness, paresthesia, serotonin syndrome, vertigo

Postmarketing reports: Aphasia, ataxia, cerebrovascular accident, extrapyramidal symptoms, grand mal seizures, stupor, tardive dyskinesia^[Ref]

Drowsiness has occurred during the first few days of treatment, and usually disappeared with continue administration.^[Ref]

Gastrointestinal

Very common (10% or more): Dry mouth (up to 34%), nausea (up to 13%), vomiting (up to 13%)

Common (1% to 10%): Abdominal disorder, constipation, diarrhea, gastric disorder

Frequency not reported: Dyspepsia, flatulence, gastroenteritis, hypersalivation, increased salivation, paralytic ileus, stomach pain

Postmarketing reports: Increased amylase^[Ref]

Cardiovascular

Very common (10% or more): Hypertension (up to 20%)

Common (1% to 10%): Edema, hypotension

Frequency not reported: Bradycardia, cardiac arrhythmias, chest pain, ECG abnormalities, increased risk of bleeding, orthostatic hypotension, palpitations, premature ventricular beats, QT prolongation, sinus bradycardia, tachycardia, Torsade de pointes, ventricular couplets, ventricular tachycardia

Postmarketing reports: Atrial fibrillation, cardiac arrest, cardiospasm, conduction block, congestive heart failure, myocardial infarction, vasodilation, ventricular ectopic activity^[Ref]

QT prolongation, Torsade de pointes, and ventricular tachycardia have been reported in patients with doses up to 100 mg/day.^[Ref]

Ocular

Very common (10% or more): Blurred vision (up to 15%)

Common (1% to 10%): Itching eyes, red eyes, tired eyes

Frequency not reported: Angle-closure glaucoma, myoclonus

Postmarketing reports: Diplopia^[Ref]

Psychiatric

Very common (10% or more): Nervousness (up to 15%)

Common (1% to 10%): Confusion

Frequency not reported: Activation of mania/hypomania, aggressive reaction, agitation (sometimes exacerbating to delirium), anxiety, cognitive impairment, confusional state, delusions, discontinuation syndrome, hallucinations, hypomania, increased libido, insomnia, libido decreased, mania, nightmares, restlessness, suicidal behavior, suicidal ideation, suicidal thoughts, withdrawal syndrome

Postmarketing reports: Abnormal dreams, paranoid reaction, psychoses^[Ref]

Other

Very common (10% or more): Fatigue (up to 11%)

Common (1% to 10%): Aches, malaise, pain

Frequency not reported: Fever, weakness

Postmarketing reports: Chills, unexplained death^[Ref]

Metabolic

Common (1% to 10%): Weight gain, weight loss

Frequency not reported: Anorexia, hyponatremia, increased appetite^[Ref]

Respiratory

Common (1% to 10%): Nasal congestion, sinus congestion

Frequency not reported: Dyspnea, shortness of breath

Postmarketing reports: Apnea^[Ref]

Dermatologic

Common (1% to 10%): Skin condition

Frequency not reported: Hyperhidrosis, pruritus, skin rash

Postmarketing reports: Alopecia, hirsutism, leuconychia, psoriasis, urticaria^[Ref]

Genitourinary

Frequency not reported: Delayed urine flow, early menses, hematuria, impotence, increased urinary frequency, micturition disorders, missed periods, priapism, retrograde ejaculation

Postmarketing reports: Breast engorgement, breast enlargement, clitorism, lactation, urinary incontinence, urinary retention^[Ref]

Hepatic

Frequency not reported: Cholestasis intrahepatic, elevated liver enzymes, fulminant hepatitis, hepatic failure with potentially fatal outcome, hepatic function abnormalities, hepatitis, hepatocellular damage, jaundice, severe hepatic disorders

Postmarketing reports: Cholestasis, hyperbilirubinemia, liver enzyme alterations^[Ref]