Desvenlafaxine Side Effects

Not all side effects for desvenlafaxine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to desvenlafaxine: oral tablet extended release

In addition to its needed effects, some unwanted effects may be caused by desvenlafaxine. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking desvenlafaxine:

Less common
  • Chills
  • cold sweats
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, pounding, or irregular pulse
  • headache
  • numbness or tingling in the arms or legs
  • shakiness in the legs, arms, hands, or feet
  • trembling or shaking of the hands or feet
  • trouble thinking, speaking, or walking
  • weakness
Incidence not known
  • Blistering, peeling, or loose skin
  • blood in the stool or urine
  • chest tightness
  • convulsions (seizures)
  • cough
  • diarrhea
  • dilated or enlarged pupils (black part of the eye)
  • feeling irritated
  • fever
  • hives, itching, rash
  • hoarseness
  • joint pain, stiffness, or swelling
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of bladder control
  • muscle pain
  • muscle spasm or jerking of all extremities
  • nosebleeds
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • red skin
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • sudden loss of consciousness
  • swelling of the eyelids, face, lips, hands, or feet
  • talking, feeling, or acting with excitement
  • trouble breathing or swallowing
  • unusual bruising
  • unusual tiredness or weakness
  • vomiting blood

Some of the side effects that can occur with desvenlafaxine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Bigger, dilated, or enlarged pupils (black part of the eye)
  • decreased appetite
  • inability to have an orgasm
  • inability to have or keep an erection
  • increased sensitivity of the eyes to light
  • loss of sexual ability, desire, drive, or performance
  • sleepiness or unusual drowsiness
  • sleeplessness
Less common
  • Change in taste
  • continuous ringing, buzzing, or other unexplained noise in the ears
  • decreased weight
  • difficult urination
  • fear or nervousness
  • hearing loss
  • increased sensitivity of the eyes to light
  • jitteriness
  • lack or loss of strength
  • loss of taste

For Healthcare Professionals

Applies to desvenlafaxine: oral tablet extended release

General

General side effects including fatigue (up to 11%), chills (up to 4%), feeling jittery (up to 3%), and asthenia (up to 2%) have been reported.

Psychiatric

Psychiatric side effects including insomnia (up to 15%), anxiety (up to 5%), abnormal dreams (up to 4%), nervousness (up to 2%), and irritability (up to 2%) have been reported. Depersonalization and hypomania have been reported infrequently.

Nervous system

Nervous system side effects including headache (up to 29%), dizziness (up to 16%), somnolence (up to 12%), tremor (up to 9%), paraesthesia (up to 3%), dysgeusia (up to 2%), and disturbance in attention (up to 2%) have been reported. Convulsion, syncope, and extrapyramidal disorders have been reported infrequently. Postmarketing reports have included anxiety, insomnia and vertigo.

Metabolic

Proteinuria was not associated with increases in BUN or creatinine and was generally transient.

Metabolic side effects including decreased appetite (up to 10%) and decreased weight (up to 2%) have been reported. Increased total cholesterol (up to 10%), increased LDL cholesterol (up to 2%), fasting triglycerides greater than or equal to 327 mg/dl (up to 6%), and proteinuria greater than or equal to trace, have been reported in the fixed dose controlled studies.

Respiratory

Respiratory side effects including yawning (up to 4%) have been reported. Epistaxis has been reported infrequently.

Ocular

Ocular side effects including mydriasis (up to 6%) and blurred vision (up to 4%) have been reported.

Cardiovascular

Cardiovascular side effects including palpitations (up to 3%), tachycardia (up to 2%), hot flushes (up to 2%), and increased blood pressure (up to 2%) have been reported. Orthostatic hypotension has been reported infrequently. In clinical studies, there were uncommon reports of ischemic cardiac adverse events, including myocardial ischemia, myocardial infarction, and coronary occlusion requiring revascularization; these patients had multiple underlying cardiac risk factors.

Dermatologic

Dermatologic side effects including hyperhidrosis (up to 21%), rash (up to 2%), and angioedema have been reported. Severe cutaneous reactions (such as Stevens-Johnson Syndrome, toxic epidermal necrolysis, and/or erythema multiforme) have been reported with other SNRIs.

Gastrointestinal

Gastrointestinal side effects including nausea (up to 41%), dry mouth (up to 25%), diarrhea (up to 11%), constipation (up to 14%), and vomiting (up to 9%) have been reported. Postmarketing reports have included decreased appetite.

Genitourinary

Genitourinary side effects including urinary hesitation (up to 2%) have been reported. Effects found in men only have included erectile dysfunction (up to 11%), anorgasmia (up to 8%), delayed ejaculation (up to 7%), decreased libido (up to 6%), ejaculation disorder (up to 5%), abnormal orgasm (up to 3%), ejaculation failure (up to 2%), and sexual dysfunction (up to 2%). Effects found in women only have included anorgasmia (up to 3%).

Hepatic

Hepatic side effects including abnormal liver function tests have been reported infrequently.

Other

In general, discontinuation events occurred more frequently with longer duration of therapy.

Other side effects including tinnitus (up to 2%) have been reported.

Adverse events reported in association with abrupt discontinuation, dose reduction, or tapering of treatment clinical studies on patients with major depressive disorder at a rate of greater than or equal to 5% include: dizziness, nausea, headache, irritability, insomnia, diarrhea, anxiety, abnormal dreams, fatigue, and hyperhidrosis.

Bruxism has also been reported.

Endocrine

Endocrine side effects including increased blood prolactin levels have been reported infrequently.

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