Desvenlafaxine Side Effects
Some side effects of desvenlafaxine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to desvenlafaxine: oral tablet extended release
Along with its needed effects, desvenlafaxine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking desvenlafaxine:Less common
- cold sweats
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast, pounding, or irregular pulse
- numbness or tingling in the arms or legs
- shakiness in the legs, arms, hands, or feet
- trembling or shaking of the hands or feet
- trouble thinking, speaking, or walking
- Blistering, peeling, or loose skin
- blood in the stool or urine
- chest tightness
- convulsions (seizures)
- dilated or enlarged pupils (black part of the eye)
- feeling irritated
- joint pain, stiffness, or swelling
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- loss of bladder control
- muscle pain
- muscle spasm or jerking of all extremities
- red skin lesions, often with a purple center
- red, irritated eyes
- red skin
- sore throat
- sores, ulcers, or white spots in the mouth or on the lips
- sudden loss of consciousness
- swelling of the eyelids, face, lips, hands, or feet
- talking, feeling, or acting with excitement
- trouble breathing or swallowing
- unusual bruising
- unusual tiredness or weakness
- vomiting blood
Some side effects of desvenlafaxine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Decreased appetite
- inability to have an orgasm
- inability to have or keep an erection
- loss of sexual ability, desire, drive, or performance
- sleepiness or unusual drowsiness
- Change in taste
- continuous ringing, buzzing, or other unexplained noise in the ears
- decreased weight
- difficult urination
- fear or nervousness
- hearing loss
- increased sensitivity of the eyes to light
- lack or loss of strength
- loss of taste
For Healthcare Professionals
Applies to desvenlafaxine: oral tablet extended release
Gastrointestinal side effects including nausea (up to 41%), dry mouth (up to 25%), diarrhea (up to 11%), constipation (up to 14%), and vomiting (up to 9%) have been reported. Postmarketing reports have included decreased appetite.
Nervous system side effects including headache (up to 29%), dizziness (up to 16%), somnolence (up to 12%), tremor (up to 9%), paraesthesia (up to 3%), dysgeusia (up to 2%), and disturbance in attention (up to 2%) have been reported. Convulsion, syncope, and extrapyramidal disorders have been reported infrequently. Postmarketing reports have included anxiety, insomnia and vertigo.
Dermatologic side effects including hyperhidrosis (up to 21%), rash (up to 2%), and angioedema have been reported. Severe cutaneous reactions (such as Stevens-Johnson Syndrome, toxic epidermal necrolysis, and/or erythema multiforme) have been reported with other SNRIs.
Psychiatric side effects including insomnia (up to 15%), anxiety (up to 5%), abnormal dreams (up to 4%), nervousness (up to 2%), and irritability (up to 2%) have been reported. Depersonalization and hypomania have been reported infrequently.
General side effects including fatigue (up to 11%), chills (up to 4%), feeling jittery (up to 3%), and asthenia (up to 2%) have been reported.
Genitourinary side effects including urinary hesitation (up to 2%) have been reported. Effects found in men only have included erectile dysfunction (up to 11%), anorgasmia (up to 8%), delayed ejaculation (up to 7%), decreased libido (up to 6%), ejaculation disorder (up to 5%), abnormal orgasm (up to 3%), ejaculation failure (up to 2%), and sexual dysfunction (up to 2%). Effects found in women only have included anorgasmia (up to 3%).
Metabolic side effects including decreased appetite (up to 10%) and decreased weight (up to 2%) have been reported. Increased total cholesterol (up to 10%), increased LDL cholesterol (up to 2%), fasting triglycerides greater than or equal to 327 mg/dl (up to 6%), and proteinuria greater than or equal to trace, have been reported in the fixed dose controlled studies.
Proteinuria was not associated with increases in BUN or creatinine and was generally transient.
Ocular side effects including mydriasis (up to 6%) and blurred vision (up to 4%) have been reported.
Cardiovascular side effects including palpitations (up to 3%), tachycardia (up to 2%), hot flushes (up to 2%), and increased blood pressure (up to 2%) have been reported. Orthostatic hypotension has been reported infrequently. In clinical studies, there were uncommon reports of ischemic cardiac adverse events, including myocardial ischemia, myocardial infarction, and coronary occlusion requiring revascularization; these patients had multiple underlying cardiac risk factors.
Respiratory side effects including yawning (up to 4%) have been reported. Epistaxis has been reported infrequently.
Other side effects including tinnitus (up to 2%) have been reported.
Adverse events reported in association with abrupt discontinuation, dose reduction, or tapering of treatment clinical studies on patients with major depressive disorder at a rate of greater than or equal to 5% include: dizziness, nausea, headache, irritability, insomnia, diarrhea, anxiety, abnormal dreams, fatigue, and hyperhidrosis.
Bruxism has also been reported.
In general, discontinuation events occurred more frequently with longer duration of therapy.
Immunologic side effects including hypersensitivity have been reported infrequently.
Hepatic side effects including abnormal liver function tests have been reported infrequently.
Endocrine side effects including increased blood prolactin levels have been reported infrequently.
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