Desoximetasone topical Side Effects

Not all side effects for desoximetasone topical may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to desoximetasone topical: topical application cream, topical application gel/jelly, topical application ointment, topical application spray

In addition to its needed effects, some unwanted effects may be caused by desoximetasone topical. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking desoximetasone topical:

Rare
  • Flushing or redness of the skin
  • redness, blistering, peeling, or loosening of the skin
  • unusually warm skin
Incidence not known
  • Blistering, burning, crusting, dryness, or flaking of the skin
  • irritation
  • itching, scaling, severe redness, soreness, or swelling of the skin
  • redness and scaling around the mouth
  • thinning of the skin with easy bruising, especially when used on the face or where the skin folds together (eg, between the fingers)
  • thinning, weakness, or wasting away of the skin

Some of the side effects that can occur with desoximetasone topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Rare
  • Burning, itching, and pain in hairy areas, or pus at the root of the hair
Incidence not known
  • Acne or pimples
  • burning and itching of the skin with pinhead-sized red blisters
  • increased hair growth on the forehead, back, arms, and legs
  • lightening of normal skin color
  • lightening of treated areas of dark skin
  • reddish purple lines on the arms, face, legs, trunk, or groin
  • softening of the skin

For Healthcare Professionals

Applies to desoximetasone topical: compounding powder, topical cream, topical gel, topical ointment, topical spray

Endocrine

Endocrine side effects have rarely included suppression of the hypothalamic-pituitary-adrenal axis. This suppression was more likely when higher potency topical corticosteroids were used over extensive areas and when occlusive dressings were used.

Local

Local side effects have commonly included burning, itching, and irritation, especially if applied to denuded skin. Adverse reactions associated with the topical spray include application site dryness, irritation, and pruritus. Long-term use of topical corticosteroids has been associated with skin atrophy and thinning, striae, telangiectasia, subcutaneous hemorrhage, and easy bruising and bleeding. Topical corticosteroid use may also inhibit local immune response, rendering the skin more susceptible to infections. Folliculitis and allergic contact dermatitis have been occasionally reported.

Skin atrophy may become evident within one to two months of use and is due to the inhibitory effect of corticosteroids on collagen formation. Skin on the face, axillae, and groin appear to be most susceptible to the adverse, long-term effects of topical desoximetasone. Use of high potency topical corticosteroids on these areas should be minimized or avoided.

Perioral dermatitis or rosacea-like dermatitis has occurred in patients with seborrheic skin type treated with potent topical corticosteroids. This condition may flare temporarily upon discontinuation of topical steroids, prompting patients to continue their use. If topical corticosteroids are discontinued, this flare and the initial dermatitis generally resolves over a few weeks.

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