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Desflurane Side Effects

Not all side effects for desflurane may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to desflurane: inhalation liquid, inhalation solution

In addition to its needed effects, some unwanted effects may be caused by desflurane. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking desflurane, check with your doctor or nurse immediately:

More common
  • Bluish lips or skin
  • body aches or pain
  • congestion
  • cough
  • dryness or soreness of the throat
  • fever
  • hoarseness
  • not breathing
  • runny nose
  • tender, swollen glands in the neck
  • tightness in the chest
  • trouble breathing
  • trouble swallowing
  • voice changes
Less common
  • Blurred vision
  • chest pain or discomfort
  • dizziness
  • fast, pounding, or irregular heartbeat or pulse
  • headache
  • lightheadedness, dizziness, or fainting
  • nervousness
  • pounding in the ears
  • slow or irregular heartbeat
  • unusual tiredness
Rare
  • Dark urine
  • difficulty with moving
  • feeling of warmth or heat
  • flushing or redness of the skin, especially on the face and neck
  • general tiredness and weakness
  • joint pain
  • light-colored stools
  • muscle aching or cramping
  • muscle pains or stiffness
  • nausea and vomiting
  • noisy breathing
  • pain or discomfort in the arms, jaw, back, or neck
  • sweating
  • swollen joints
  • upper right abdominal or stomach pain
  • yellow eyes and skin
Incidence not known
  • Abdominal or stomach pain
  • confusion
  • convulsions
  • decreased urine
  • dry mouth
  • increased thirst
  • loss of appetite
  • no blood pressure or pulse
  • numbness or tingling in the hands, feet, or lips
  • stopping of heart
  • unconsciousness
  • weakness or heaviness of the legs

Some of the side effects that can occur with desflurane may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Increased watering of the mouth
  • redness of the white part of the eyes or inside of the eyelids
Rare
  • Anxiety
  • hyperventilation
  • irritability
  • itching skin
  • restlessness
  • shaking
  • trouble sleeping

For Healthcare Professionals

Applies to desflurane: inhalation liquid

Respiratory

Respiratory side effects including coughing (34%), breathholding (up to 30%), apnea (15%), increased secretions, laryngospasm, oxyhemoglobin desaturation, pharyngitis, increased cough, dyspnea, respiratory arrest, respiratory failure, respiratory distress, bronchospasm, hemoptysis, and hypoxia have been reported.[Ref]

Gastrointestinal

Gastrointestinal side effects including nausea (27%), vomiting (16%), acute pancreatitis, and abdominal pain have been reported.[Ref]

Cardiovascular

Cardiovascular side effects including bradycardia, hypertension, nodal arrhythmia, tachycardia, arrhythmia, bigeminy, abnormal electrocardiogram, myocardial ischemia, vasodilation, hemorrhage, cardiac arrest, Torsade de pointes, ventricular failure, ventricular hypokinesia, malignant hypertension, hypotension,
and myocardial infarct have been reported.[Ref]

Nervous system

Nervous system side effects including increased salivation, agitation, convulsion, and dizziness have been reported.[Ref]

Hepatic

Hepatic side effects including hepatitis, hepatic failure, hepatic necrosis, cytolytic hepatitis, cholestasis, jaundice, abnormal hepatic function, liver disorder, increased transaminases, increased alanine aminotransferase, and increased aspartate aminotransferase
have been reported.

General

General side effects including shock, malignant hyperthermia, asthenia, malaise, headache, and fever have been reported.[Ref]

Ocular

Ocular side effects including conjunctivitis (conjunctival hyperemia) and ocular icterus have been reported.[Ref]

Metabolic

Metabolic side effects including hyperkalemia, hypokalemia, metabolic acidosis, and increased creatinine phosphokinase have been reported.[Ref]

Musculoskeletal

Musculoskeletal side effects including myalgia and rhabdomyolysis have been reported.[Ref]

Dermatologic

Dermatologic side effects including urticaria, erythema, and pruritus have been reported.[Ref]

Hematologic

Hematologic side effects including coagulopathy have been reported.

References

1. "Product Information. Suprane (desflurane)." Baxter Pharmaceutical Products, Inc, New Providence, NJ.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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