Depen Side Effects

Generic Name: penicillamine

Please note - some side effects for Depen may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of Depen - for the Consumer

Depen Titratabs

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Depen Titratabs:

Diarrhea; loss of appetite; mild stomach pain; nausea; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; bleeding or bruising; blood in the urine; burning, itching, peeling, or redness of skin; changes in taste; chills; cough; dark urine; difficult urination; fever; general feeling of discomfort; joint pain; muscle weakness; severe stomach pain; shortness of breath; skin lesions; sore throat; swelling of the feet or legs; vision problems; weight gain; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Depen

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Depen:

Diarrhea; loss of appetite; mild stomach pain; nausea; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; bleeding or bruising; blood in the urine; burning, itching, peeling, or redness of skin; changes in taste; chills; cough; dark urine; difficult urination; fever; general feeling of discomfort; joint pain; muscle weakness; severe stomach pain; shortness of breath; skin lesions; sore throat; swelling of the feet or legs; vision problems; weight gain; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Side Effects by Body System - for Healthcare Professionals

Nervous system

Nervous system side effects have included tinnitus, myasthenia gravis, polyradiculopathy (rare), peripheral sensory and motor neuropathies (including polyradiculoneuropathy). Muscular weakness may or may not occur with the peripheral neuropathies.

Ocular

Ocular side effects have included reversible optic neuritis with racemic penicillamine (may be related to pyridoxine deficiency).

Gastrointestinal

Gastrointestinal side effects have included anorexia, epigastric pain, nausea, vomiting, and occasional diarrhea (17%). Some patients may report a blunting, diminution, or total loss of taste perception (12%); or may develop oral ulcerations. Although rare, cheilosis, glossitis, and gingivostomatitis have been reported.

Hematologic

Hematologic side effects have included thrombocytopenia (4%), leukopenia (2%), and bone marrow depression. Fatalities have been reported as a result of thrombocytopenia, agranulocytosis, aplastic anemia, and sideroblastic anemia.

Renal

Renal side effects have included proteinuria (6%) and/or hematuria which, in some, may progress to the development of the nephrotic syndrome as a result of an immune complex membranous glomerulopathy. Renal failure and a severe and ultimately fatal renal vasculitis have also been reported.

Musculoskeletal

Musculoskeletal side effects have included myasthenia gravis and dystonia.

Dermatologic

Dermatologic side effects have included skin friability, excessive wrinkling of skin, toxic epidermal necrolysis, anetoderma, development of small white papules at venipuncture and surgical sites, lichen planus, and bullous pemphigoid.

Respiratory

Respiratory side effects have included allergic alveolitis, obliterative bronchiolitis, interstitial pneumonitis, pulmonary fibrosis, and bronchial asthma.

Other

Other side effects have included hyperpyrexia, alopecia, and Goodpasture's syndrome.

Other

The chelating action of the drug may cause increased excretion of other heavy metals such as zinc, mercury, and lead.

Local

Local side effects have included thrombophlebitis.

Genitourinary

Genitourinary side effects have included mammary atrophy.

Immunologic

Immunologic side effects have included polymyositis and dermatomyositis.

Oncologic

There have been reports associating penicillamine with leukemia. However, circumstances involved in these reports are such that a cause and effect relationship to penicillamine has not been established.

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