Demerol HCl Side Effects
Generic Name: meperidine, meperidine hydrochloride
Please note - some side effects for Demerol HCl may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
Side Effects by Body System - for Healthcare Professionals
Applies to: compounding powder; injectable solution; intravenous solution; oral syrup; oral tablet
Central nervous system side effects have included sleepiness, lightheadedness, sedation, sweating, agitation, tremor, mood changes (e.g., euphoria, dysphoria), weakness, headache, disorientation, respiratory depression, delirium, seizures, tremors, dizziness, visual disturbances (e.g., transient hallucinations), muscle twitches, dilated pupils, and Parkinsonian symptoms.
Central nervous system side effects may be either depressant or excitatory. Excitatory symptoms are sometimes ignored as possible side effects of meperidine, but may be due to the accumulation of a metabolite, normeperidine. Accumulation of normeperidine occurs more frequently in patients with renal insufficiency and in patients who are receiving meperidine via a patient-controlled analgesia pump.
Severe adverse effects, such as respiratory depression, may be treated with the opioid antagonist naloxone.
Psychiatric side effects include fearfulness, agitation, paranoia, hypervigilance, and auditory and visual hallucinations.
Psychological dependence on meperidine may develop.
Meperidine may cause contraction of the sphincter of Oddi, thereby increasing intrabiliary pressure. As a result, meperidine may aggravate rather than relieve biliary colic.
Constipation is less common with meperidine than some other narcotics.
Gastrointestinal side effects including increased gastroesophageal reflux, increased biliary pressure, dry mouth, nausea, and vomiting have been reported.
Hypersensitivity side effects including anaphylaxis and shock have been reported.
Other side effects including an opioid abstinence or withdrawal syndrome has been reported.
The opioid abstinence or withdrawal syndrome is characterized by some or all of the following: restlessness, lacrimation, rhinorrhea, yawning, perspiration, chills, myalgia, mydriasis. Other symptoms also may also develop, including: irritability, anxiety, backache, joint pain, weakness, abdominal cramps, insomnia, nausea, anorexia, vomiting, diarrhea, or increased blood pressure, respiratory rate, or heart rate.
There are case reports of bronchospasm occurring in patients with a history of asthma after receiving meperidine. Because of this effect and possible respiratory depression, meperidine should be used with caution in patients with severe reactive or obstructive pulmonary disease.
Respiratory side effects including bronchospasm have been reported in patients with underlying pulmonary disease.
Hypotension occurs most commonly in patients who are under anesthesia, who are dehydrated, and who are receiving other medications.
Cardiovascular side effects including phlebitis have been reported. Hypotension has been reported rarely.
Genitourinary side effects including urinary retention have been reported.
Dermatologic side effects including rash, pruritus, and sweating have been reported.
Musculoskeletal side effects including a case of meperidine-induced muscular rigidity have been reported.Top
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