DDAVP Side Effects
Generic name: desmopressin
Note: This document contains side effect information about desmopressin. Some of the dosage forms listed on this page may not apply to the brand name DDAVP.
Some side effects of DDAVP may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to desmopressin: solution, spray, tablet
Along with its needed effects, desmopressin (the active ingredient contained in DDAVP) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking desmopressin:Rare
- convulsions (seizures)
- decreased urination
- fast heartbeat
- headache (continuing)
- shortness of breath, tightness in chest, trouble in breathing, or wheezing
- skin rash, hives, or itching
- weight gain (rapid)
Some side effects of desmopressin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less common or rare
- Abdominal or stomach cramps
- flushing or redness of skin
- pain in the vulva (genital area outside of the vagina)
- runny or stuffy nose
- sore throat
- Pain, redness, or swelling at place of injection
For Healthcare Professionals
Applies to desmopressin: injectable solution, nasal solution, nasal spray, oral tablet
One review of the literature found that the incidence of thrombotic events associated with the use of DDAVP to reduce blood loss and transfusion requirements in surgical patients was not significantly higher than placebo. In any case, the incidence of thrombosis is rare. One review found only 10 reports of thrombosis over a 4-year period, covering 433,000 doses of DDAVP.
Cardiovascular side effects have infrequently included transient and slight elevations or reductions in blood pressure, a compensatory change in heart rate, and facial flushing with injections of desmopressin (DDAVP). Vasodilation and water retention have occurred. There have been rare reports of thrombotic events (acute cerebral thrombosis, acute myocardial infarction) in some patients after DDAVP injection. At least one case of fatal left coronary thrombosis has been associated with the use of DDAVP.
The risk factors for DDAVP-induced hyponatremia include stress, surgery, anesthesia, narcotics (endogenous release of ADH), vomiting (loss of sodium), liver disease (hindered metabolism of DDAVP), overhydration with hyponatremic fluids, and advanced age. In some cases, fluid restriction, avoidance of hyponatremic solutions, and close monitoring of serum electrolytes and urine output for at least 15 to 20 hours after the administration of DDAVP may be beneficial.
Nervous system side effects have included seizures and/or coma as a result of severe water intoxication and hyponatremia. Other nervous system side effects have included headache and dizziness in less than 3% of patients. DDAVP nasal spray has been infrequently associated with somnolence, lethargy, paresthesias, fatigue, confusion, stupor, malaise, diaphoresis, itchy or light-sensitive eyes, insomnia, chills, warm feeling, and agitation.
Hematologic side effects have included platelet aggregation and thrombocytopenia. These have been seen almost uniquely in patients with von Willebrand's disease Type IIB (DDAVP is contraindicated in these patients).
Local side effects of injections of DDAVP have included intravenous site erythema, swelling, and burning.
Respiratory side effects of intranasal DDAVP have included rhinitis, epistaxis, and nostril pain in 2% to 10% of patients. Apnea and cardiac arrest occurred in one patient.
Gastrointestinal side effects have included mild abdominal cramps and nausea in 2% of patients. Dyspepsia and vomiting have rarely been associated with DDAVP nasal spray.
Hypersensitivity reactions have rarely included anaphylaxis.
Psychiatric side effects have included a single case of paranoid psychosis associated with the use of DDAVP nasal spray.
More DDAVP resources
- DDAVP MedFacts Consumer Leaflet (Wolters Kluwer)
- DDAVP Prescribing Information (FDA)
- DDAVP Advanced Consumer (Micromedex) - Includes Dosage Information
- DDAVP Concise Consumer Information (Cerner Multum)
- Desmopressin Prescribing Information (FDA)
- DDAVP Rhinal Tube Prescribing Information (FDA)
- DDAVP Rhinal Tube nasal Concise Consumer Information (Cerner Multum)
- Desmopressin Acetate Monograph (AHFS DI)
- Minirin spray MedFacts Consumer Leaflet (Wolters Kluwer)
- Stimate Prescribing Information (FDA)
- Stimate spray MedFacts Consumer Leaflet (Wolters Kluwer)
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.