Daunorubicin liposomal Side Effects

Medically reviewed by Drugs.com. Last updated on Jan 4, 2024.

Applies to daunorubicin liposomal: intravenous dispersion.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, or have back pain and chest tightness.

Call your doctor at once if you have:

• chest pain, shortness of breath (even with mild exertion), swelling, rapid weight gain;

• fever, chills, body aches, flu symptoms, sores in your mouth and throat;

• easy bruising, unusual bleeding (nose, mouth, vagina, or rectum);

• nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

• pain, burning, irritation, or skin changes where the injection was given.

Common side effects may include:

• mild nausea, vomiting, diarrhea, stomach pain;

• cough;

• headache;

• temporary hair loss, mild itching or rash; or

• red colored urine for 1 or 2 days following a dose.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to daunorubicin liposomal: intravenous dispersion.

Hematologic

Very common (10% or more): Bone marrow suppression, bone marrow failure, agranulocytosis, neutropenia, febrile neutropenia, leucopenia, pancytopenia, thrombocytopenia, anemia, hemorrhage^[Ref]

Cardiovascular

Common (1% to 10%): Decreased left ventricular ejection fraction

Uncommon (0.1% to 1%): Congestive heart failure, cardiomyopathy

Rare (less than 0.1%): Atrial fibrillation, myocardial infarction

Frequency not reported: Shock^[Ref]

Dermatologic

Very common (10% or more): Alopecia

Rare (less than 0.1%): Palmar-plantar erythrodysesthesia syndrome^[Ref]

Gastrointestinal

Very common (10% or more): Stomatitis, mucous ulcerations, nausea, vomiting, diarrhea, abdominal pain^[Ref]

Local

Very common (10% or more): Infusion-associated reactions (e.g., back pain, flushing, chest tightness, dyspnea, allergic reaction), extravasation at the injection site (erythema, pain, swelling)^[Ref]

Hepatic

Frequency not reported: Transient elevations in serum bilirubin, transient elevations in aspartate aminotransferase (AST), transient elevations in alkaline phosphatase (ALP), hepatitis, hepatic failure^[Ref]

Other

Very common (10% or more): Asthenia, fatigue, fever, chills^[Ref]

Immunologic

Very common (10% or more): infections

Uncommon (0.1% to 1%): Sepsis, septic shock^[Ref]

Metabolic

Common (1% to 10%): Dehydration^[Ref]

Genitourinary

Frequency not reported: Red discoloration of urine, amenorrhea, azoospermia^[Ref]

Hypersensitivity

Very common (10% or more): Allergic reaction

Rare (less than 0.1%): Anaphylactic reaction^[Ref]

Psychiatric

Common (1% to 10%): Depression^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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