Cyanokit Side Effects

Generic name: hydroxocobalamin

Note: This document contains side effect information about hydroxocobalamin. Some of the dosage forms listed on this page may not apply to the brand name Cyanokit.

Some side effects of Cyanokit may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to hydroxocobalamin: injectable solution, intravenous powder for injection

Get emergency medical help if you have any of these signs of an allergic reaction while taking hydroxocobalamin (the active ingredient contained in Cyanokit) hives; chest tightness, difficulty breathing; swelling of your face, lips, tongue, or throat.

You may develop an acne-like skin rash within 1 to 4 weeks after you are treated with hydroxocobalamin. This rash should go away without treatment. Call your doctor if you have a rash that lasts longer than 4 weeks.

Call your doctor at once if you have a serious side effect such as:

• bright red blood in your stools;

• chest pain, fast or uneven heart rate;

• severe shortness of breath, wheezing, gasping for breath, cough with foamy mucus;

• swelling in your feet or ankles;

• feeling like you might pass out; or

• dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Less serious side effects of hydroxocobalamin may include:

• red coloring of your urine (may last up to 5 weeks);

• red coloring of your skin (may last up to 2 weeks);

• eye redness or irritation;

• acne, mild skin rash;

• nausea, vomiting, diarrhea, stomach pain;

• dry throat, trouble swallowing;

• headache, dizziness, memory problems, restless feeling;

• hot flashes; or

• pain, swelling, or irritation of your skin where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to hydroxocobalamin: compounding powder, injectable solution, intravenous powder for injection

Gastrointestinal

Gastrointestinal side effects have included mild transient diarrhea and nausea.

Other

Other side effects have included itching and feeling of swelling of the entire body.

Dermatologic

Dermatologic side effects have included transitory exanthema and erythema.

Hypersensitivity

Hypersensitivity side effects have rarely included anaphylactic reactions.

Local

Local side effects have included infusion site reaction and pain with injection.

Renal

Renal side effects have included chromaturia.

Cardiovascular

Cardiovascular side effects, following intravenous administration, have included increased blood pressure.

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