Cuprimine Side Effects
Generic name: penicillamine
Note: This document contains side effect information about penicillamine. Some of the dosage forms listed on this page may not apply to the brand name Cuprimine.
Some side effects of Cuprimine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to penicillamine: oral capsule, oral tablet
If you experience any of the following serious side effects, seek emergency medical attention or contact your doctor immediately:
an allergic reaction (shortness of breath; closing of your throat; difficulty breathing; swelling of your lips, face, or tongue; or hives);
fever or chills;
a sore throat;
unusual bleeding or bruising;
blood in the urine;
unexplained shortness of breath, coughing, or wheezing;
yellow skin or eyes;
muscle weakness; or
Other, less serious side effects may be more likely to occur. Continue to take penicillamine (the active ingredient contained in Cuprimine) and notify your doctor if you experience
itching or a rash;
nausea, vomiting, diarrhea, or decreased appetite;
ringing in the ears;
sores in the mouth;
poor wound healing; or
increased wrinkling of the skin.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
For Healthcare Professionals
Applies to penicillamine: oral capsule, oral tablet
Nervous system side effects have included tinnitus, myasthenia gravis, polyradiculopathy (rare), peripheral sensory and motor neuropathies (including polyradiculoneuropathy). Muscular weakness may or may not occur with the peripheral neuropathies.
Ocular side effects have included reversible optic neuritis with racemic penicillamine (the active ingredient contained in Cuprimine) (may be related to pyridoxine deficiency).
Gastrointestinal side effects have included anorexia, epigastric pain, nausea, vomiting, and occasional diarrhea (17%). Some patients may report a blunting, diminution, or total loss of taste perception (12%); or may develop oral ulcerations. Although rare, cheilosis, glossitis, and gingivostomatitis have been reported.
Hematologic side effects have included thrombocytopenia (4%), leukopenia (2%), and bone marrow depression. Fatalities have been reported as a result of thrombocytopenia, agranulocytosis, aplastic anemia, and sideroblastic anemia.
Renal side effects have included proteinuria (6%) and/or hematuria which, in some, may progress to the development of the nephrotic syndrome as a result of an immune complex membranous glomerulopathy. Renal failure and a severe and ultimately fatal renal vasculitis have also been reported.
Musculoskeletal side effects have included myasthenia gravis and dystonia.
Dermatologic side effects have included skin friability, excessive wrinkling of skin, toxic epidermal necrolysis, anetoderma, development of small white papules at venipuncture and surgical sites, lichen planus, and bullous pemphigoid.
Respiratory side effects have included allergic alveolitis, obliterative bronchiolitis, interstitial pneumonitis, pulmonary fibrosis, and bronchial asthma.
Other side effects have included hyperpyrexia, alopecia, and Goodpasture's syndrome.
The chelating action of the drug may cause increased excretion of other heavy metals such as zinc, mercury, and lead.
Local side effects have included thrombophlebitis.
Genitourinary side effects have included mammary atrophy.
Immunologic side effects have included polymyositis and dermatomyositis.
There have been reports associating penicillamine (the active ingredient contained in Cuprimine) with leukemia. However, circumstances involved in these reports are such that a cause and effect relationship to penicillamine has not been established.
More Cuprimine resources
- Cuprimine Prescribing Information (FDA)
- Cuprimine MedFacts Consumer Leaflet (Wolters Kluwer)
- Cuprimine Concise Consumer Information (Cerner Multum)
- Cuprimine Advanced Consumer (Micromedex) - Includes Dosage Information
- Depen Prescribing Information (FDA)
- Penicillamine Professional Patient Advice (Wolters Kluwer)
- Penicillamine Monograph (AHFS DI)
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