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Cromolyn Side Effects

Not all side effects for cromolyn may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to cromolyn: inhalation aerosol liquid, inhalation aerosol powder, inhalation capsule, inhalation solution

Other dosage forms:

Along with its needed effects, cromolyn may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking cromolyn:

  • Difficulty in swallowing
  • hives
  • increased wheezing or difficulty in breathing
  • itching of skin
  • low blood pressure
  • shortness of breath
  • swelling of face, lips, or eyelids
  • tightness in chest

Some side effects of cromolyn may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Coughing
  • nausea
  • throat irritation or dryness

If you are using the cromolyn inhalation aerosol, you may notice an unpleasant taste. This may be expected and will go away when you stop using the medicine.

For Healthcare Professionals

Applies to cromolyn: compounding powder, inhalation aerosol with adapter, inhalation solution, nasal spray, oral capsule, oral solution


Hypersensitivity reactions have included anaphylaxis. Hypersensitivity side effects have been reported to develop after weeks to years of use.


Respiratory side effects have included throat irritation and transient cough and bronchospasm after inhalation of cromolyn powder by Spinhaler. Nasal congestion has been associated with cromolyn use. Pulmonary infiltrates and pulmonary granulomatosis have been rarely reported. Wheezing and chest tightness following cromolyn use have preceded more serious allergic reactions.

Throat irritation may be relieved by drinking water before and after inhalation of cromolyn. Use of a beta-2 agonist prior to cromolyn inhalation may relieve cough and bronchospasm.


Hematologic side effects have included leukocytosis and eosinophilia.


Genitourinary side effects have included urinary burning and irritation.


Dermatologic side effects have included facial or generalized dermatitis, urticaria, and rarely, vasculitis.


Gastrointestinal side effects have been reported with inhaled cromolyn, including nausea, vomiting, and rarely, esophagitis. Symptoms of lactose intolerance have been reported in a patient with lactase deficiency receiving cromolyn capsules by inhalation.


Hepatic side effects have included liver disease, with eosinophilic infiltrates, in association with eosinophilia.


Cardiovascular side effects have included a single case report of cardiac tamponade associated with eosinophilia.


Musculoskeletal system side effects have rarely included myositis, which involved the lower extremities resulting in pain and fatigue.

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