Colestipol Side Effects

Some side effects of colestipol may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to colestipol: oral powder for suspension, oral tablet

Along with its needed effects, colestipol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking colestipol:

Rare
  • Black, tarry stools
  • stomach pain (severe) with nausea and vomiting

Check with your doctor as soon as possible if any of the following side effects occur while taking colestipol:

More common
  • Constipation
Rare
  • Loss of weight (sudden)

Some side effects of colestipol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Belching
  • bloating
  • diarrhea
  • dizziness
  • headache
  • nausea or vomiting
  • stomach pain

For Healthcare Professionals

Applies to colestipol: oral granule for reconstitution, oral tablet

Gastrointestinal

Gastrointestinal side effects occur in the majority of patients. In one study, up to 68% of patients complained of gastrointestinal side effects. Constipation is most common and can be severe. Intestinal obstruction is reported with another bile acid sequestrant; elderly and pediatric patients treated with colestipol may be at risk for this as well. Increases in fluid intake as well as dietary fiber may help to reduce the severity of constipation. In general, gastrointestinal side effects tend to diminish with continued therapy. If gastrointestinal side effects are significant, dosage reduction, even if temporary, may be beneficial.

Gastrointestinal side effects include constipation (10 to 28%), heartburn (17%), abdominal discomfort (11%), nausea (9%), belching, flatulence, vomiting, and diarrhea. Peptic ulceration, gastrointestinal irritation and bleeding, cholecystitis, cholelithiasis, and anorexia have been reported rarely.

Hematologic

Hematologic side effects include a single report of prolonged prothrombin time responsive to vitamin K supplementation.

Hepatic

Hepatic side effects include transient elevations in serum glutamic oxaloacetic transaminase and alkaline phosphatase.

Nervous system

Nervous system side effects include headache, dizziness, and, very rarely, anxiety, vertigo, and drowsiness.

Hypersensitivity

Hypersensitivity reactions have included urticaria and dermatitis.

Musculoskeletal

Musculoskeletal side effects include rare reports of muscle pain, joint pain, and arthritis.

Metabolic

Metabolic side effects include increases in serum phosphorus and chloride and decreases in serum sodium and potassium. Colestipol has been reported to decrease the absorption of thyroxine (T4).

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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