Codeine / phenylephrine Side Effects

Some side effects of codeine / phenylephrine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to codeine / phenylephrine: liquid

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; excitability; headache; nausea; nervousness or anxiety; stomach pain; trouble sleeping.

Seek medical attention right away if any of these SEVERE side effects occur while taking codeine / phenylephrine:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; confusion; difficulty urinating; fast, slow, or irregular heartbeat; hallucinations; loss of coordination; mental or mood changes; numbness or tingling of the skin; persistent loss of appetite; persistent trouble sleeping; ringing in the ears; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; shortness of breath; tremor; wheezing.

For Healthcare Professionals

Applies to codeine / phenylephrine: oral liquid

Nervous system

Nervous system side effects have included sedation, dizziness, sleepiness, disturbed coordination, fatigue, confusion, restlessness, excitation, nervousness, tremor, irritability, insomnia, euphoria, paresthesias, vertigo, hysteria, neuritis, tinnitus, acute labyrinthitis, and convulsions.

Ocular

Ocular side effects have included blurred vision and diplopia.

Gastrointestinal

Gastrointestinal side effects have included epigastric distress, anorexia, nausea, vomiting, diarrhea, and constipation.

Genitourinary

Genitourinary side effects have included urinary frequency, difficult urination, urinary retention, and early menses.

Respiratory

Respiratory side effects have included thickening of bronchial secretions, tightness of chest, wheezing, dryness of mouth, nose and throat, and nasal stuffiness.

Dermatologic

Dermatologic side effects have included urticaria, drug rash, photosensitivity, and pruritis.

Hypersensitivity

Hypersensitivity side effects have included anaphylactic shock.

Cardiovascular

Cardiovascular side effects have included hypotension, palpitations, tachycardia, and extra systoles.

Hematologic

Hematologic side effects have included hemolytic anemia, thrombocytopenia, and agranulocytosis.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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