Cocaine topical Side Effects

Not all side effects for cocaine topical may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to cocaine topical: topical paste, topical solution

In addition to its needed effects, some unwanted effects may be caused by cocaine topical. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking cocaine topical, check with your doctor or nurse immediately:

Less common or Rare
  • Abdominal or stomach pain
  • chills
  • confusion
  • dizziness or lightheadedness
  • excitement, nervousness, restlessness, or any mood or mental changes
  • fast or irregular heartbeat
  • general feeling of discomfort or illness
  • hallucinations or seeing, hearing, or feeling things that are not there
  • headache (sudden)
  • increased sweating
  • nausea

Some of the side effects that can occur with cocaine topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Loss of sense of taste or smell (after use in the nose or mouth)

For Healthcare Professionals

Applies to cocaine topical: compounding powder, topical solution

Nervous system

Nervous system side effects have included nervousness, restlessness, excitement, tremors, and seizures (tonic-clonic).[Ref]

Cardiovascular

Cardiovascular side effects have included vasoconstriction, bradycardia associated with small doses, and increased heart rate associated with moderate doses.[Ref]

Respiratory

Respiratory side effects have included fatal respiratory failure secondary to depression of the central nervous system.[Ref]

Ocular

Ocular side effects have included mydriasis. Sloughing of the corneal epithelium, clouding, pitting, and corneal ulceration have been reported.[Ref]

Gastrointestinal

Gastrointestinal side effects have included vomiting.[Ref]

General

In general, most side effects are probably due to the high plasma drug levels resulting from excessive and rapid absorption of cocaine topical.[Ref]

References

1. "Product Information. Cocaine Hydrochloride (cocaine topical)." Mallinckrodt Medical Inc, St. Louis, MO.

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