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Clocortolone topical Side Effects

Not all side effects for clocortolone topical may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to clocortolone topical: topical cream

Get emergency medical help if you have any of these signs of an allergic reaction while taking clocortolone topical: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Topical steroid medicine can be absorbed through the skin, which may cause steroid side effects throughout the body. Stop using clocortolone topical and call your doctor if you have:

  • blurred vision, or seeing halos around lights;

  • uneven heartbeats;

  • sleep problems (insomnia);

  • weight gain, puffiness in your face; or

  • tired feeling.

Also stop using clocortolone topical and call your doctor at once if you have:

  • severe skin irritation where the medicine was applied; or

  • signs of skin infection (swelling, redness, warmtth, oozing).

Common side effects may include:

  • burning or itching of treated skin;

  • skin dryness or irritation;

  • increased hair growth;

  • acne, skin rash;

  • folliculitis (redness or crusting around your hair follicles);

  • stretch marks;

  • lightened color of treated skin; or

  • white or "pruned" appearance of the skin (caused by leaving wound dressings on for long periods of time).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to clocortolone topical: topical cream


The most commonly reported side effects were burning, itching, irritation, and dryness.[Ref]


Frequency not reported: Hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing's syndrome[Ref]

Nervous system

Frequency not reported: Intracranial hypertension (including bulging fontanelles, headaches, bilateral papilledema)[Ref]


Frequency not reported: Hyperglycemia, glucosuria[Ref]


Frequency not reported: Folliculitis, hypertrichosis, acneform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria[Ref]


Frequency not reported: Burning, itching, irritation, dryness[Ref]


1. "Product Information. Cloderm (clocortolone topical)" Hermal Pharmaceutical Labs Inc, Delmar, NY.

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