Clindamycin and tretinoin Side Effects

Please note - some side effects for Clindamycin and tretinoin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects by Body System - for Healthcare Professionals

Local

Local side effects including skin erythema, scaling, itching, burning, and stinging have been reported.

Respiratory

Respiratory side effects including nasopharyngitis, pharyngolaryngeal pain, cough, and sinusitis have been reported in greater than 1% of patients.

Dermatologic

Dermatologic side effects including dry skin have been reported in greater than 1% of patients.

Other

Other side effects have included one case of ringing in the ear and partial hearing loss believed to be caused by clindamycin.

A 14-year-old boy developed reproducible ringing in his right ear and hearing loss while using topical clindamycin and after discontinuing use. He underwent a complete physical exam and labs which failed to find a cause for his symptoms. The patient was restarted on benzoyl peroxide/clindamycin topical and the ringing in his ear increased. He was told to stop all medications and was started on methylprednisolone. The tinnitus decreased in 1 to 2 days with no improvement in the hearing deficit. After the third time he was restarted on benzoyl peroxide/clindamycin gel, the tinnitus returned at an increased level together with right-sided headaches within 1 to 2 days. The patient again stopped using the benzoyl peroxide and clindamycin gel and the tinnitus returned to a low level over 1 to 2 days. It is believed that the clindamycin component played a part in this patient's tinnitus and hearing loss.

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